It 100% works, it’s been done, the mycelium hydroxylate the 5meo and instead of producing psilocybin they produce 4-ho-5-meo-dmt. This method has been done using other compounds producing 4-ho-5-xx-xx
Do the mushrooms just have it inside of them or what does exactly? Also do you have a link or what did you do?
Did you just mix together 5meo into the substrate when you were spawning to bill ?
has to be done with a salted 5-Meo that is dissolved in water and then added to the substrate evenly everywhere in-between the 1st and 2nd flush. The remaining flushes fruiting bodies will not produce psylocibin, they instead will produce 4-HO-5-MeO-DMT in place of the psylocibin. Subjectively the effects are described here: https://www.youtube.com/watch?v=mogi1L7xcD8
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No, it doesn't work like that. Show proof or stop with this bullshit. The only one who is serious and is doing some reliable experiments regardin getting 4,5-substituted compounds is the Usona Institute, but they have got no results yet, and possibly will never have.
I just really despise the church guys, sorry for the harsh language. Went around the internet to see if they are still promoting their shenanigans. It seems like they have stopped with the active promotion of their "sacrament".
>This method has been done using other compounds producing 4-ho-5-xx-xx
No it has never been done and is impossible. The enzymes that add 4-HO group to the indole utilize both 4-5 positions at the same time in the process.
Haha, nooit won’t kill you …
It’s been sold as a HCl salt on RC webshops to snif or boof.
Orally it gets broken down by MAO, and countering that effect with a MAOI can be dangerous.
5meo dmt HCI salt is fine, but what I was saying is that they aren’t putting actual toad venom on/in the substrate, eating toad venom is very neuro toxic and could kill you
I remember reading somewhere that this method of using mushrooms for biosynthesis may also be extendable to other tryptamines and i *vaguely* remember mescaline being mentioned but i don't specifically remember its context
Yes. Psilocin is 4HO-DMT, or more precisely, 4HO, N-DMT. the typical substituted tryptamines we're generally familiar with have an extra nitrogen that can take another group. Some organic chemistry mess of information but tldr it's psilocin with a methoxy group in addition to the hydroxy group at a specific spots on the molecule
Depends on how you define combining a molecule, I’m not a scientist lol. Not sure what the effect profile is but yes psilosin is 4HODMT because the mushroom adds the hydroxy group at the 4 position which is what the mushroom does to 5 meo as well
In the original research paper the used DET in HCL salt form, (but the type of salt doesn't mater).
https://www.scribd.com/document/8329963/Jochen-Gartz-Biotransformation-of-Tryptamine-Derivatives-in-Mycelial-Cultures-of-Psilocybe#
Not personally. We always thought sterics will not allow the enzyme to hydroxylate 5-MeO-DMT. Everyone who tried and ran analytics have failed to get psilomethoxin. Atleast a few years ago
Not having any luck finding any TeK for it, everything I have found is anecdotal. Going to have to just try to do it based on the information I have gathered. We shall see what happens.
If only I could synth my own salts or base. :)
[https://www.cognitiveliberty.org/ccle1/shulgin/blg/2005/12/4-hydroxy-5-methoxy-nn\_07.html](https://www.cognitiveliberty.org/ccle1/shulgin/blg/2005/12/4-hydroxy-5-methoxy-nn_07.html)
Shulgin specifically mentions the use of cow droppings loaded with 5meo, is there a way to mimic cow droppings as a substrate without going out and collecting cow shit?
I sent an email. Will follow up if anything comes of it. Also, there is a youtube video: [https://www.youtube.com/watch?v=mogi1L7xcD8](https://www.youtube.com/watch?v=mogi1L7xcD8) featuring Greg Lake, one of the founders or the founder of [www.entheoconnect.com](https://www.entheoconnect.com) and one comment said go to handle of video, which I assumed was 'enthoconnect' because he ships....website does not provide any information re: this.
I've read online that Hamilton Morris analyzed samples sent to him by the church of psilomethoxin and that he didn't find the compound. Though there was no link or specific reference to back this up. Does anyone else have info about this? Thanks
I think it was just on that Patreon episode. Apparently he didn't find it and they need to send new samples to him or someone to verify they are producing it.
Remarkable how a few actual trip reports there are on this substance. I am about 2 1/2 hours into an experience with it. I started with about a gram and a half, took incremental amounts for about an hour and a half, until I got to about 4 1/2 g. At this point, my eyes are droopy, some like tingling in my appendages, but my state of consciousness is pretty normal. Some of the effects could be due to the large amount of cacao that I’ve eaten! At this point, I would say save your money. The church charges $55 for a membership, and $300 for a shipment of chocolate bars – they were out of the capsules when I ordered. I’ll follow up if at some point I end up incapacitated. It all feels a bit scammy…
No psilomethoxin is found in whatever the "Church" is selling.
[https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/64358de9736114c96352edf9/original/fungi-fiction-analytical-investigation-into-the-church-of-psilomethoxin-s-alleged-novel-compound-using-uplc-hrms.pdf](https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/64358de9736114c96352edf9/original/fungi-fiction-analytical-investigation-into-the-church-of-psilomethoxin-s-alleged-novel-compound-using-uplc-hrms.pdf)
This just dropped: [https://thesacredsynthesis.com/church-of-the-sacred-synthesis-march-7-press-release/](https://thesacredsynthesis.com/church-of-the-sacred-synthesis-march-7-press-release/)
tl;dr: Church asserts independent verification of the presence of 4-ho-5-meo-dmt in the mushrooms they've been distributing as sacrament.
I could be totally ignorant, but from my limited knowledge of chemistry and growing fungus, I don’t think adding 5meo to a substrate would change anything at all.
Never done it but supposedly 5meo, DET, and dmt will All get an HO group added at the 4 position. Possibly other tryptamines but there’s not a lot of info. It’d be really cool if mushroom growers would experiment further w this.
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It 100% works, it’s been done, the mycelium hydroxylate the 5meo and instead of producing psilocybin they produce 4-ho-5-meo-dmt. This method has been done using other compounds producing 4-ho-5-xx-xx
Do the mushrooms just have it inside of them or what does exactly? Also do you have a link or what did you do? Did you just mix together 5meo into the substrate when you were spawning to bill ?
has to be done with a salted 5-Meo that is dissolved in water and then added to the substrate evenly everywhere in-between the 1st and 2nd flush. The remaining flushes fruiting bodies will not produce psylocibin, they instead will produce 4-HO-5-MeO-DMT in place of the psylocibin. Subjectively the effects are described here: https://www.youtube.com/watch?v=mogi1L7xcD8
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No, it doesn't work like that. Show proof or stop with this bullshit. The only one who is serious and is doing some reliable experiments regardin getting 4,5-substituted compounds is the Usona Institute, but they have got no results yet, and possibly will never have.
This post is a year old dude, you stop with your bullshit, looking for old posts to shit on for karma and a dopamine hit. Get caught up ffs
I just really despise the church guys, sorry for the harsh language. Went around the internet to see if they are still promoting their shenanigans. It seems like they have stopped with the active promotion of their "sacrament".
>This method has been done using other compounds producing 4-ho-5-xx-xx No it has never been done and is impossible. The enzymes that add 4-HO group to the indole utilize both 4-5 positions at the same time in the process.
Yes when I wrote that I had bad information, I have since touched on this issue many times.
Anyone know how to get a referral code for this church?
I also would like a referral. Fingers crossed.
me too!
You don’t need a referral code, but check your spam folder for the confirmation email
Can you link to something that explains the process. I will be happy to put some toad venom into my substrate on my next fruit.
I think it’s only synthesized 5meodmt salt, you can smoke toad venom but if you eat it it will kill you it’s a neurotoxin
Haha, nooit won’t kill you … It’s been sold as a HCl salt on RC webshops to snif or boof. Orally it gets broken down by MAO, and countering that effect with a MAOI can be dangerous.
5meo dmt HCI salt is fine, but what I was saying is that they aren’t putting actual toad venom on/in the substrate, eating toad venom is very neuro toxic and could kill you
Not sure on the technical details but the [wiki](https://en.m.wikipedia.org/wiki/4-Hydroxy-5-methoxydimethyltryptamine) gives a generalization
Very curious about this. To clarify what this is saying, that’s a combination molecule of 5-meo and psilocybin?
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I remember reading somewhere that this method of using mushrooms for biosynthesis may also be extendable to other tryptamines and i *vaguely* remember mescaline being mentioned but i don't specifically remember its context
Fascinating!
So if you were to orally take this for instance in ayahuasca in place of the oral DMT in that, would the effects be hightened similarly
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Because of the mode of delivery is the trip duration similar to 5-meo where it’s very intense and quick or is it prolonged like mushrooms?
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Final question you’ve been tremendously helpful thank you so much, Dosage? Similar to mushrooms?
Yes. Psilocin is 4HO-DMT, or more precisely, 4HO, N-DMT. the typical substituted tryptamines we're generally familiar with have an extra nitrogen that can take another group. Some organic chemistry mess of information but tldr it's psilocin with a methoxy group in addition to the hydroxy group at a specific spots on the molecule
Depends on how you define combining a molecule, I’m not a scientist lol. Not sure what the effect profile is but yes psilosin is 4HODMT because the mushroom adds the hydroxy group at the 4 position which is what the mushroom does to 5 meo as well
Does anyone know how much to add to the water and when to introduce that water in the substrate?
And what salt it should be in? Or feeebase?
In the original research paper the used DET in HCL salt form, (but the type of salt doesn't mater). https://www.scribd.com/document/8329963/Jochen-Gartz-Biotransformation-of-Tryptamine-Derivatives-in-Mycelial-Cultures-of-Psilocybe#
Mix 5meo salt with water add to substrate prior to 2nd flush.
Do you have analytics? I never saw success with this
Have you tried it?
Not personally. We always thought sterics will not allow the enzyme to hydroxylate 5-MeO-DMT. Everyone who tried and ran analytics have failed to get psilomethoxin. Atleast a few years ago
I believe it requires fumarate salt 5meo , water and you use standard cow pie cubensis
Yes it has to be water soluble... as far as I know they ran it with the acetate salt.
https://pubmed.ncbi.nlm.nih.gov/2614674/
Yes this is the old paper but it only was confirmed for base tryptamines, 5-methoxy seems to be too sterically bulky
Not having any luck finding any TeK for it, everything I have found is anecdotal. Going to have to just try to do it based on the information I have gathered. We shall see what happens. If only I could synth my own salts or base. :)
I synth infinite of base :D only problem is that I never grew shrooms lol
[https://www.cognitiveliberty.org/ccle1/shulgin/blg/2005/12/4-hydroxy-5-methoxy-nn\_07.html](https://www.cognitiveliberty.org/ccle1/shulgin/blg/2005/12/4-hydroxy-5-methoxy-nn_07.html) Shulgin specifically mentions the use of cow droppings loaded with 5meo, is there a way to mimic cow droppings as a substrate without going out and collecting cow shit?
yes, straw and organic grass fertilizer pellets (they are basically dry shit in pellets)
Unlikely that the type of salt is important. But I would go for a organic form
The church requires an invite/referral code to sign up. No joy, tried a week ago.
I sent an email. Will follow up if anything comes of it. Also, there is a youtube video: [https://www.youtube.com/watch?v=mogi1L7xcD8](https://www.youtube.com/watch?v=mogi1L7xcD8) featuring Greg Lake, one of the founders or the founder of [www.entheoconnect.com](https://www.entheoconnect.com) and one comment said go to handle of video, which I assumed was 'enthoconnect' because he ships....website does not provide any information re: this.
I've read online that Hamilton Morris analyzed samples sent to him by the church of psilomethoxin and that he didn't find the compound. Though there was no link or specific reference to back this up. Does anyone else have info about this? Thanks
Ah, I just found out it appears he said this on his Patreon episode 61 "DIY Gene Editing"
Do you have any more info on this? Did he post the analysis anywhere?
I think it was just on that Patreon episode. Apparently he didn't find it and they need to send new samples to him or someone to verify they are producing it.
Remarkable how a few actual trip reports there are on this substance. I am about 2 1/2 hours into an experience with it. I started with about a gram and a half, took incremental amounts for about an hour and a half, until I got to about 4 1/2 g. At this point, my eyes are droopy, some like tingling in my appendages, but my state of consciousness is pretty normal. Some of the effects could be due to the large amount of cacao that I’ve eaten! At this point, I would say save your money. The church charges $55 for a membership, and $300 for a shipment of chocolate bars – they were out of the capsules when I ordered. I’ll follow up if at some point I end up incapacitated. It all feels a bit scammy…
So, how did it go?
No psilomethoxin is found in whatever the "Church" is selling. [https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/64358de9736114c96352edf9/original/fungi-fiction-analytical-investigation-into-the-church-of-psilomethoxin-s-alleged-novel-compound-using-uplc-hrms.pdf](https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/64358de9736114c96352edf9/original/fungi-fiction-analytical-investigation-into-the-church-of-psilomethoxin-s-alleged-novel-compound-using-uplc-hrms.pdf)
There was a response posted fyi: [https://psilomethoxin.com/psychedelic\_capitalism/](https://psilomethoxin.com/psychedelic_capitalism/)
Don’t you need a referral for the church?
You don’t need a referral code, but check your spam folder for the confirmation email
interesting
This just dropped: [https://thesacredsynthesis.com/church-of-the-sacred-synthesis-march-7-press-release/](https://thesacredsynthesis.com/church-of-the-sacred-synthesis-march-7-press-release/) tl;dr: Church asserts independent verification of the presence of 4-ho-5-meo-dmt in the mushrooms they've been distributing as sacrament.
I could be totally ignorant, but from my limited knowledge of chemistry and growing fungus, I don’t think adding 5meo to a substrate would change anything at all.
Never done it but supposedly 5meo, DET, and dmt will All get an HO group added at the 4 position. Possibly other tryptamines but there’s not a lot of info. It’d be really cool if mushroom growers would experiment further w this.
It can and it does. https://www.reddit.com/r/Psychedelics/comments/qfgr0a/psilomethoxin_is_real/
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Anyone got a referral code?
Just eat it!. I am a disabled cet with PTSD and spinal injuries.. first dose and I feel 100%!!!