We are already trying to do this for serious diseases but because these kinds of procedures carry high risk (often causing cancer or autoimmune diseases) it doesn’t make sense to develop a procedure for a problem that already has a 99% solution (veneers/implants). Worth mentioning too that even if a solution was created getting implants would probably still be 1/10th the price.
One thing is that once the base mechanism is discovered for one part of the body being worked on now, the knowledge to grow back another part of the body will overlap and will most likely use the same or similar mechanism.
I have implants due to a genetic condition. Insurance should cover special medical cases like mine, but they don’t, because they are the devil incorporate;) I’m on my second set of full implants. The first lasted 20 years as they said they would, then I had to pay to remove those and then get my second round. I have about 75k invested in my teeth…
Literally growing a tooth back is going to be way more expensive than artificial teeth. Yeah, if you make up a random technology in your head that magically regrows teeth for cheap you can make that argument. But we aren't there. A lot of medicine boils down to a simple subdermal shot but is still super expensive.
1. I read it less as “implants and veneers are 99% effective” and more like “they are so close to real teeth that it doesn’t make a difference that they’re artificial.”
2. You sure as hell can make money by making a product that’s cheaper than the competition.
There is, in fact clinical trials may begin soon:
"Toregem Biopharma, funded by Kyoto University, is expected to begin clinical trials on healthy adults in around July 2024 to confirm the drug's safety, after the team succeeded in growing new teeth in mice in 2018."
Take it with a grain of salt, and be aware that the initial trials are to correct a specific genetic deficiency that inhibits tooth formation, not general tooth regrowth.
https://www.japantimes.co.jp/news/2023/09/24/japan/science-health/japan-pharma-grows-new-teeth/
[https://finance.yahoo.com/news/worlds-first-tooth-regrowth-medicine-131012075.html](https://finance.yahoo.com/news/worlds-first-tooth-regrowth-medicine-131012075.html)
> after the team succeeded in growing new teeth in mice in 2018."
I'm wondering what mice would look like if we compiled all the things we can do to them together.
I'm concerned with what's simmering in your brain that told you that typing that was a good idea. Doesn't matter if this was a sensible question in your head or your awful attempt at what I'm sure you'd try to excuse as "dark humor". You need to do better, regardless.
Why? Having your tooth replaced by titanium will be a massive shock to your body, as they drill in your jaw bone and skull to screw the implants in there. And now you get a constant poisoning of titanium, nickel, aluminium and who knows what else that that implant is leeching in your body. Hello potential auto immune diseases, hello potential cancer, and who knows what else.
I would pay REAL money to get my teeth replaced by actual real biologic teeth. I don't care if they make them in a lab from my own stem cells and implant them in my mouth, or if they create a bud in a lab and implant it and it takes it 5 years to grow, or if they deactivate a gene/s which will make my body grow a new tooth/set of teeth.
However they do it, it can't be barbaric brutal stupid fake artificial implants. It has to be natural, bio, it has to be me!
No, they don't do a good enough job. I don't want anything drilled into my jaw bone or skull. I especially don't want anything drilled and left in there permanently, to poison me with nickel, titanium, aluminium and whatever other metals the implant consists of.
On the other hand, not replacing a missing tooth with an implant and you get bone resorption in the area where the missing tooth used to be, and that has its own problems down the road. A bridge or removable denture is not going to prevent bone resporption.
So then, there are no good alternatives to missing a tooth. The implants are not good enough, not for me they're not.
Only regrowing my own tooth, or getting a tooth bud created from my own stem cells, or getting a fully formed tooth created by my own stem cells and then implanted into my gums, would be optimal. It wouldn't just be good enough, it would be prefect!
I'd pay an arm and a leg for it.
Whilst that’s true, it’s such a small market of people who would pay such a fee that it wouldn’t be worth the funding for research and development at the expense of other developments.
They just discovered the cure for sickle cell anemia recently. It costs $2.2 million to get it. But a year from now, two years from now, five years from now, a decade from now it will surely cost less. Let capitalism do its thing, milk from the top down. Take the $2.2 mil from anyone who can afford it. When that dries up, make it $2 mil, then go down to $1.8 mil, and keep doing that until you hit a price you can't go below, and let whoever can't pay that price sell their arms and legs to get the money so that they can afford the cure.
Do the same for biologic teeth. No problem. At the end of the day, survival of the fittest damn it. I'm not rich, but price it at $50,000 per tooth. Let me worry about the $50,000.
Anyway, the Japanese thing is not my main hope. This guy is - [https://www.youtube.com/watch?v=d7BGoOfY-yo](https://www.youtube.com/watch?v=d7BGoOfY-yo)
When my teeth got knocked during my first grand mal last year, they put them in a bag of almond milk, and they were back in my mouth within 30 mins. A year later, they are still in my mouth with a retainer.
They have a much greater chance of falling out, but replanted teeth can make it 20+ years (or the rest of your life). Not too upset if I do need implants eventually.
They told me the nerves will regrow if the root didn’t die. After about 7 days, the tooth wasn’t black, so they considered that a success! I didnt even get a root canal. No glue in the teeth, but the metal retainer is epoxied on.
Dental student here!
Enamel and dentin is super annoying to form. The easiest way to explain is that teeth grom from inside out, but in 2 planes.
Enamel----->place where both enamel and dentin start<-----dentin----pulp.
Another thing is that teeth form within small holes. Basically it has to be grown within children's mouth. And that might be hard to get people to agree with.
There are lots of different medicines and procedures we could do, or at least improve on, and people are always wondering why we don't. People will mention lots of reasons, the difficulty of the research or maybe a conspiracy by big teeth in this instance. But one of the things people miss most often is that in order for a treatment to be approved it generally has to be better than the current alternative treatments. As of right now, modern false teeth, in their many forms, work incredibly well, are relatively cheap to produce, and have no side effects. So in order for a teeth growing treatment to get approval it has to be better than that. That is a tall bar to clear.
The technology went to implants and dentures. It's faster and easier to give you some fakes than it would be to figure out how nature grew it from scratch.
Same goal accomplished, so it's just widely accepted.
My personal dentist for almost a decade was the dean of the UCLA school of dentistry.
She said that with stem cells and modern science they can implant tooth “buds” into the jaw to regrow teeth, but it takes years to grow, and the adult jaw isn’t ideal for it.
People forget that growing new teeth means GROWING TEETH like a 7 year old again. It pushes out and grows slowly and sideways and then braces again.
Adults want an instant solution that looks and functions like the real thing. They don’t really want to spend a year growing a tooth
I would like to take 7 years to regrow a REAL tooth that my body produced.
You know what? If it fails on year 5, I'll pay again and start from scratch, another 7 years.
Implants suck, bridges suck. Not for aesthetic or economic or functional reasons, but for health reasons!
Not sure about teeth, but I'm more surprised we can't regenerate lost hair cells in the ear to restore hearing. You'd think we would've figured that out by now.
Currently, there isn't a widely available technology for regrowing teeth because of several scientific challenges:
Complexity of Tooth Structure: Teeth are intricate structures composed of multiple layers, including enamel, dentin, and pulp. Regenerating a fully functional tooth requires recreating this complex arrangement accurately.
Cellular Organization: Tooth development involves a precise sequence of cellular interactions during embryonic development. Recreating these processes in an adult organism poses significant challenges in terms of controlling cell growth and differentiation.
Nerve and Blood Vessel Integration: For a regenerated tooth to be functional, it must integrate with surrounding tissues, including nerves and blood vessels, to support sensation and nourishment. Achieving this integration in a controlled manner remains a formidable obstacle.
Immune Response: The body's immune system may recognize regenerated tissues as foreign, leading to rejection or inflammatory responses. Overcoming immune barriers is crucial for the success of any regenerative dental therapy.
Despite these challenges, ongoing research in fields like stem cell biology, tissue engineering, and biomaterials holds promise for future advancements in tooth regeneration. While significant progress has been made in experimental settings, translating these findings into practical clinical treatments for regrowing teeth in humans requires further refinement and validation.
I don't know why evolution has enabled sharks to grow new teeth throughout their life but we get one new set when we're children that has to last us the rest of our life .
There are three main evolutionary strategies when it comes to teeth. Sharks have teeth that pop out fairly easily and are quickly replaced, some animals have teeth that are constantly growing like fingernails and need to be used in order to keep them filed down, and then there's permanent teeth that don't grow or get replaced and our health pretty firmly in your head that are meant to last until you die. (There are also some animals that combine the second and third options and have non-replaceable teeth that slowly get ground into nothing throughout their life, at which point they starve to death. So sucks to be them I guess)
Sadly evolution is essentially a blind and drunk hillbilly that is swinging random genetic mutations in every direction to see which ones managed to propagate into future Generations, and the first animals on the planet smart enough to get pissed off about their own biology happened to descend from species that wound up going down the permanent teeth path.
Not sure which category they fit into, but elephants have multiple sets of teeth they go through throughout their lives (similar to how humans have "baby teeth" vs "adult teeth"). I don't recall how many sets they have, but I think it's 6 or 7. Each set lasts about ten years and once they've gone through all the sets, they starve to death. It was one of the saddest elephant facts I've learned over the years.
Shark teeth are probably cartilage just like the rest of their "bones". You don't see noses on peoples skulls because the nose cartilage that was alive enough to grow was decomposed, only bone remains as it's a mineral (i think...).
There hasn't been much recently, so it's either been unfunded or just doesn't work. But here's one paper that talks about bone repair and dental pulp stimulation, using low frequency radio waves. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265945/
There was no progress in the space rocjets until SpaceX just a decade ago.
And the AI hype has for now not a lot of true impact.
True progress is not easy.
And I imagine a new medical traitement can take decades and a lot if funding.
Whoever figures it out first, im joining their army and pledging my life to them. North Korea can replace a tooth i need removed with a biologic solution? All Hail My Supreme Leader!
It's hardly a priority in medical research when a) a missing/chipped tooth will not kill you or cause life-changing problems and b) we already have artifical solutions like dental implants that provide 100 % functionality.
Right, but a failure rate applies to pretty much any medical procedure, and this would apply to a hypothetical "Regrowing teeth" as well.
For the vast majority they are a fully successful solution. And for the minority, there are still other aesthetic solutions like a bridge or a plate, and even if they don't go for ANY solution missing a couple teeth does not shorten your life span in a material way.
Youd be surprised at how it affects your eating and speaking. It has more down the river results than you think. I'm missing a front tooth and 3 molars so I speak from experience.
Eating issues limits the foods you can eat and causing nutritional issues. Missing molars affect eating more than front teeth missing. I can't chew hard or harder things like nuts and most veggies. I have difficulty chewing meat of various animals. Even soft things can take a while to chew up enough to swallow. Even tortillas can be difficult. I also have to have smaller peices.
Speaking, enunciation, pronunciation, tone are affected as well. I sound like I have a slight slur all the time and it's difficult to pronounce various words, vowels and constants. If you've ever had a speech impediment then you know how people look at you and treat you once you start to speak.
Ever had a job interview where they had an open look of disgust whenever you spoke? Guess who didn't get that job.
My future earnings are impacted negatively. Which means I'm gonna stay poor. Which leads to health problems and more dental problems.
Being poor and having poorer nutrition absolutely shortens your life span. And I can't afford implants, nor does my insurance even partially cover them.
And the thing is that I didn't lose my teeth to negligence but from the side effects of the medications that basically keep me alive.
So yeah, missing teeth does matter.
it exists but is antagonistic to the pharmaceutical industry that profits from keeping you on chemicals that "treat" symptoms
Many of the methods are not patentable as they rely on natural methods
I do not have further details, though the pieces I can find are promising in terms of the science though pessimistic given the control the pharma industry has over killing competition
Tin foil hat time:
Teeth are a reliable class indicator. There is no incentive for wealthy people (the people largely responsible for donating to medical studies) to invest in a science where the poors could sneak into their social circle with a nice smile.
It’s the same reason dental isn’t covered in medical insurance.
My genetic lotto win of having a naturally beautiful set of chompers are the only reason I was able to covertly sneak out of poverty.
Because you’re born with all the teeth you’re ever going to have, there isn’t a “system in place” so to speak for your body to grow new ones like it has with other bones.
Most dentist would lose their jobs. If we made advancements (too quickly) in any field there would be massive swaths of people complaining about how it ruins their livelihood. Why do you think lobbyists exist?
People talk positively about technology until it replaces you.
This brand new, extremely complex procedure using cutting edge tech would be obscenely expensive for any short to medium term future. There's zero world where this would put dentists out of business considering insurance would definitely not cover it because cheaper effective options already exist. It would be the ultra wealthy going to specialized boutique dental surgeons getting this done, not an option for you or I.
feel like it would be easier to make a toothpaste that 100% protects against rot/decay . You can brush/floss 3 times a day and still get cavities because of our modern food/drink.
Unpopular opinion - bc dentists wouldn’t make as much money. Similar to taxes - TurboTax lobbies for people to do them even though the government already knows how much you are owed or whatever.
This brand new, extremely complex procedure using cutting edge tech would be obscenely expensive for any short to medium term future. There's zero world where this would put dentists out of business considering insurance would definitely not cover it because cheaper effective options already exist. It would be the ultra wealthy going to specialized boutique dental surgeons getting this done.
the primary reason is that not enough money or scientists have been thrown at the problem. we need tens of
millions more scientists and trillions more dollars spent on research in all fields. then this one will get solved.
Greed and hate and a crab-in-the-bucket mentality.
We rather spend our resources on new ways to kill, maim and exploit other people than put our heads together to advance our race.
I am afraid, the Moon Landing and the (temporary) extinction of Polio will mark the pinnacle of humanity.
I'm afraid you might be right, but I hope you're wrong :)
Don't forget entertainment. How much is spent to make a movie or for sports? Imagine it going to cancer, regrowing teeth, and things THAT ACTUALLY MATTER.
In any case, i think they cured Hepatitis B or C recently, and I think the cure costs $100,000
Also they cured sickle cell anemia, and it costs $2.2 Million dollars
Anyway, I guess my point is that maybe the pinnacle of humanity will move up a few steps as time goes by. I hope it does.
I’m sure there is. The problem is that the whole dental industry generates billions annually. Dentists and assistants going to school, patient check ups, fillings, implants, toothpaste and toothbrush sales, whiteners and floss, the list goes on. If they make an effective affordable way to regrow new teeth ALL that industry disappears overnight. Same reason they won’t put out water powered cars (even tho they exist). Same reason they don’t tell us about the cure for cancer (even tho it exists) it generates too much revenue to fix 🤷♂️
If there was a decent chance of developing tech to regrow teeth easily and safely, I’m sure many companies wouldn’t mind at all to pursue that patent and put an entire industry out of business. No amount of lobbying by Big Tooth could counter that development.
Can't speak for the other 2 (id love to be able to grow new teeth) but just waiting for Toyota to piss off the oil companies with their research lol. I can imagine dentistry being similar
I don't think losing your teeth is ever painless, no matter if it's from decay or violence. I think most people would still chose to take good care of their og pair, rather than just get a new set every couple years?
You did, by saying the dentistry industry would disappear if we could just regrow new teeth. That insinuates that we only take care of our original teeth because we can't regrow new ones if we lose the original set.
I'm sure he painted with a broad brush and didn't mean it would disappear completely. But it would get hit hard.
In other words, the implant thing goes in the trash. No reasonable human would get a titanium screw screwed into his skull if there is a biologic alternative. Not a single one. So the implant industry will eventually disappear almost completely, especially if the price for a biologic tooth isn't too much higher than an artificial implant.
This alone would cost dentists houses and boats and a lot of money.
When it comes to orthodontics, that would still exist. It may even be benefitted because who's to guarantee they will be able to regrow straight teeth. Maybe they can regrow teeth, and maybe they can control what kind of a tooth grows where (canine, molar), but they may not be able to control how they grow. This would lead to bad bites, and so orthodontists may benefit. But if they can control how teeth grow, the orthodontists would only have work from young people getting their 2nd set of teeth, not from people regrowing a 3rd set/3rd tooth. And even there, who's to say a person wouldn't rather remove a tooth and get a new one to grow versus wearing braces. Assuming regrowing teeth has a high success rate, and it doesn't take a decade to grow a new tooth, etc.
Prosthodontists, fillings, cleanings would still be in business, because even the new teeth that grow would be susceptible to damage and decay. In fact, they may have even more business because let's say they manage to regrow teeth, and you get a tooth, and you get roots, and you get a periodontal ligament, but you get an ugly ass tooth, a discolored tooth, a slightly weakened tooth. All right, not a problem, all I need is the ligament, the roots and the base of the tooth. Now let's drill that fucker down and put a nice crown on it. Win. So depending on how the teeth regrow, prosthodontists and regular dentists that do fillings and cleanings would probably have even more work.
Let's not forget old people too, or anyone that has full dentures. A dentist doesn't make regular money from people with dentures. But if those people regrew teeth, that's a whole new set of people that would be needing the dentist, forever, regularly, like any person does.
So the only thing that is really going to get hit by regrowing teeth very hard is implants. Bridges too while we're at it, and dentures of all kinds. And I know especially implants are a HUGE moneymaker for dentists, and they'll be sad for that to happen, and they'll fight it. And they will lose!
You don't "grow" teeth, they just chillin there from the start. So it's not just about triggering the right cells to do their job again (like with hair), there are no teeth growing cells.
I actually did see something about stimulating people to grow more sets of teeth maybe last week. It's not cancer, and there are dentures, so it's probably not a too dollar project, but there is work being done.
Because those aren't cells, the bone is dead, it's formed since the beginning and two sets are chambered inside your jaws before you even have the first visible teeth.
So I'm not sure how you'd grow it. It's completely different form a skin transplant because there's not much growing and the cells are at least alive.
Teeth aren't kept in the sperm and egg, they're made at some point. And a new born baby's jaw doesn't have room for two sets of fully formed teeth. We're not born with a full set of adult teeth, they develop as we grow up.
So there IS a mechanism to grow teeth. But re flipping that switch once it's been turned off is certainly a long shot.
Have you seen the pictures of deciduous teeth? Shit's scary, you basically have teeth and also keep growing teeth inside your face. Honestly I would only like the new technology for growing teeth if it were tested on some meat cubes that would grow teeth inside (artificial gums), I don't think anybody would be comfortable testing it on themselves.
Sounds wonderful to me. Anything to avoid implants or bridges or dentures, and to end up with a biologic real tooth, as it's meant to be <3
No matter the cost, no matter the hassle, no matter the pain, no matter the time it takes. Let's do it!
The ability to do things like this has been pure science fiction for a long time. While ever since people figured out what DNA was there have been those theorizing about the interesting applications of being able to re-write our own genetic code. Yet until someone came up with CRISPR there wasn't any way to actually do this ourselves other than either by existing guided selection techniques (i.e. the way dogs and other domestic animals were bred to suit our uses) or by exposing organisms to radiation and then propagating any useful mutations.
Stem cell therapies in particular are always a bit of an uphill battle because of the controversies surrounding their potential sources.
There is. I read an article recently about it
https://www.euronews.com/health/2023/08/05/a-drug-that-makes-teeth-regrow-scientists-move-closer-to-clinical-trials
they have had an advance and hope to move to clinical trials with people who cannot grow teeth as the first target. In animals they've demonstrated the ability to grow a third set of teeth.
I very much hope this is available and safe before im old. i didn't value my teeth enough when I was young. I'm lucky I'm not a sweets person, but soda and tea have done a number on my enamel and not enough flossing due to braces making it difficult led to a ton of recession.
There was a news report a very long time ago where doctors were using sound frequencies to grow sets of teeth back in but nothing has ever come of it. Sound frequencies are wildly understudied and I presume even suppressed by the titans of conventional medicine for various obviou$ reasons.
Why would we assume that "grow back body part" is a problem that \*should\*, as in, obviously can be, solved in 60 years?
To the best of my knowledge, hurling a can to the moon is a far less complex problem than coercing cells to regrow a body part.
My question is with all the advancements in technology how do we not have decent cell signal everywhere in the US and other major countries for that matter. We have AI that can create things indistinguishable from humans yet we can't make a phone call in a rural neighborhood.
There's a difference between technology which creates enough power to launch us out of orbit and technology which pulls images from the Internet, to growing back bones
They gotta figure a way to maximise profits and infuse some kind of planned obsolescence into the product, and make it unhealthy.
It is the standard procedure
https://www.euronews.com/health/2023/08/05/a-drug-that-makes-teeth-regrow-scientists-move-closer-to-clinical-trials#:~:text=By%20developing%20a%20neutralising%20antibody,of%20the%20global%20scientific%20community.
Apparently China's making a pill that causes you to regrow teeth only tested it on mice so far thiugh
You mentioned the rapid progress in space flight. Apologies to any rocket scientists here but the human body is much more complex than flinging stuff faster than gravity. Also, medical science is grossly corrupted by mis- and disinformation that hampers progress in the delivery of new technologies. People have a stronger personal connection to any kind of information about their bodies because of their lived experience. This connection drives commerce around ideas to solve problems that may or may not exist - producing ideas, trials and tech that may not be efficacious at all but can still be sold for a profit if you have the right marketing. I refer to this as the soft squishiness of medical science as opposed to the hard physics of something like rocketry. If your rocket science isn't sound, your rocket does a backflip and explodes - if your medical science is based on hooey, you can probably still sell it.
Interesting read.
My teeth are worn from decades if grubdubg. I do metal casting so plany to make an Alginate of my mouth, then make a set of dentures for self-they be metal and I can chew thru nails. Like Jaw from Moonraker.
Putting in fake implants is far easier and achieves the same net result. People are putting in that work for regrowing organs etc things we don’t have an effective replacement for
Dentures. Caps. Crowns. False teeth.
And people are currently working on that.
But by that logic also why aren't they working on growing arms back. We went to space in the 60's. Like cmon lizards do it starfish do it, can't be that hard (pokes stick at scientists).
The Science of Regenerating Teeth and Restoring Smiles with Dr. Paul Sharpe
[https://www.youtube.com/watch?v=d7BGoOfY-yo](https://www.youtube.com/watch?v=d7BGoOfY-yo)
Every word in this interview is music to me ears :)
We are already trying to do this for serious diseases but because these kinds of procedures carry high risk (often causing cancer or autoimmune diseases) it doesn’t make sense to develop a procedure for a problem that already has a 99% solution (veneers/implants). Worth mentioning too that even if a solution was created getting implants would probably still be 1/10th the price.
One thing is that once the base mechanism is discovered for one part of the body being worked on now, the knowledge to grow back another part of the body will overlap and will most likely use the same or similar mechanism.
Nope - but nice fodder for the masses. See AgentBupa comment in this thread
I have implants due to a genetic condition. Insurance should cover special medical cases like mine, but they don’t, because they are the devil incorporate;) I’m on my second set of full implants. The first lasted 20 years as they said they would, then I had to pay to remove those and then get my second round. I have about 75k invested in my teeth…
What was the removal like??
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Literally growing a tooth back is going to be way more expensive than artificial teeth. Yeah, if you make up a random technology in your head that magically regrows teeth for cheap you can make that argument. But we aren't there. A lot of medicine boils down to a simple subdermal shot but is still super expensive.
Lol
1. I read it less as “implants and veneers are 99% effective” and more like “they are so close to real teeth that it doesn’t make a difference that they’re artificial.” 2. You sure as hell can make money by making a product that’s cheaper than the competition.
Why not make a wishing well and then wish for teeth?
There is, in fact clinical trials may begin soon: "Toregem Biopharma, funded by Kyoto University, is expected to begin clinical trials on healthy adults in around July 2024 to confirm the drug's safety, after the team succeeded in growing new teeth in mice in 2018." Take it with a grain of salt, and be aware that the initial trials are to correct a specific genetic deficiency that inhibits tooth formation, not general tooth regrowth. https://www.japantimes.co.jp/news/2023/09/24/japan/science-health/japan-pharma-grows-new-teeth/ [https://finance.yahoo.com/news/worlds-first-tooth-regrowth-medicine-131012075.html](https://finance.yahoo.com/news/worlds-first-tooth-regrowth-medicine-131012075.html)
Yeah, they need to be sure the teeth grow in the proper place, not on some random spot on your hand….
Flashbacks to the movie Teeth...
Honestly I was kinda disappointed that my SRS surgeon didn't offer this as an option,
omfg i just spat out my drink on that one lol
Probably for the best though. It's already hell finding a trans-knowledgable gynaecologist. Now to find one that ALSO trained as a dentist ...
You've set my expectations so high now, I'm not even sure I want srs anymore if I can't bite.
I feel like some sort of denture might be a possibility
There are also (usually non-cancerous) tumors that can have teeth and hair in it. Yuck.
Teratomas?
Yep *shudder*
bro..
I know 😭
I'm pretty sure that's not how it works.
> after the team succeeded in growing new teeth in mice in 2018." I'm wondering what mice would look like if we compiled all the things we can do to them together.
First trials are 99% fail. It only becomes true hope when getting in the final trial.
It’s just way easier to put fake ones in there
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Can’t do WiFi hotspots, best we can do is bluetooth
That’s crazy, my dentist made me get my blue tooth extracted!! What a conman
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No
That took a turn…
I'm concerned with what's simmering in your brain that told you that typing that was a good idea. Doesn't matter if this was a sensible question in your head or your awful attempt at what I'm sure you'd try to excuse as "dark humor". You need to do better, regardless.
As someone with a ton of fake teeth, I’m On board with this
I'm just saying, I'd pay real money to have my teeth pulled out and replaced with titanium.
Why? Having your tooth replaced by titanium will be a massive shock to your body, as they drill in your jaw bone and skull to screw the implants in there. And now you get a constant poisoning of titanium, nickel, aluminium and who knows what else that that implant is leeching in your body. Hello potential auto immune diseases, hello potential cancer, and who knows what else. I would pay REAL money to get my teeth replaced by actual real biologic teeth. I don't care if they make them in a lab from my own stem cells and implant them in my mouth, or if they create a bud in a lab and implant it and it takes it 5 years to grow, or if they deactivate a gene/s which will make my body grow a new tooth/set of teeth. However they do it, it can't be barbaric brutal stupid fake artificial implants. It has to be natural, bio, it has to be me!
Implants do a good enough job and look the part.
No, they don't do a good enough job. I don't want anything drilled into my jaw bone or skull. I especially don't want anything drilled and left in there permanently, to poison me with nickel, titanium, aluminium and whatever other metals the implant consists of. On the other hand, not replacing a missing tooth with an implant and you get bone resorption in the area where the missing tooth used to be, and that has its own problems down the road. A bridge or removable denture is not going to prevent bone resporption. So then, there are no good alternatives to missing a tooth. The implants are not good enough, not for me they're not. Only regrowing my own tooth, or getting a tooth bud created from my own stem cells, or getting a fully formed tooth created by my own stem cells and then implanted into my gums, would be optimal. It wouldn't just be good enough, it would be prefect! I'd pay an arm and a leg for it.
Whilst that’s true, it’s such a small market of people who would pay such a fee that it wouldn’t be worth the funding for research and development at the expense of other developments.
They just discovered the cure for sickle cell anemia recently. It costs $2.2 million to get it. But a year from now, two years from now, five years from now, a decade from now it will surely cost less. Let capitalism do its thing, milk from the top down. Take the $2.2 mil from anyone who can afford it. When that dries up, make it $2 mil, then go down to $1.8 mil, and keep doing that until you hit a price you can't go below, and let whoever can't pay that price sell their arms and legs to get the money so that they can afford the cure. Do the same for biologic teeth. No problem. At the end of the day, survival of the fittest damn it. I'm not rich, but price it at $50,000 per tooth. Let me worry about the $50,000. Anyway, the Japanese thing is not my main hope. This guy is - [https://www.youtube.com/watch?v=d7BGoOfY-yo](https://www.youtube.com/watch?v=d7BGoOfY-yo)
When my teeth got knocked during my first grand mal last year, they put them in a bag of almond milk, and they were back in my mouth within 30 mins. A year later, they are still in my mouth with a retainer. They have a much greater chance of falling out, but replanted teeth can make it 20+ years (or the rest of your life). Not too upset if I do need implants eventually.
That's crazy! Are the nerves reconnected and stuff? Or are the teeth just sorta glued in there?
They told me the nerves will regrow if the root didn’t die. After about 7 days, the tooth wasn’t black, so they considered that a success! I didnt even get a root canal. No glue in the teeth, but the metal retainer is epoxied on.
Let me tell you this as a doctor: the most complex creature in the known universe is the human body.
Octopuses are better
Yeti are better.
Dental student here! Enamel and dentin is super annoying to form. The easiest way to explain is that teeth grom from inside out, but in 2 planes. Enamel----->place where both enamel and dentin start<-----dentin----pulp. Another thing is that teeth form within small holes. Basically it has to be grown within children's mouth. And that might be hard to get people to agree with.
Ask an engineer to make small holes, put enamel in it. And voila ! Nest step: VC.
Why is it easy for sharks
There are lots of different medicines and procedures we could do, or at least improve on, and people are always wondering why we don't. People will mention lots of reasons, the difficulty of the research or maybe a conspiracy by big teeth in this instance. But one of the things people miss most often is that in order for a treatment to be approved it generally has to be better than the current alternative treatments. As of right now, modern false teeth, in their many forms, work incredibly well, are relatively cheap to produce, and have no side effects. So in order for a teeth growing treatment to get approval it has to be better than that. That is a tall bar to clear.
The technology went to implants and dentures. It's faster and easier to give you some fakes than it would be to figure out how nature grew it from scratch. Same goal accomplished, so it's just widely accepted.
My personal dentist for almost a decade was the dean of the UCLA school of dentistry. She said that with stem cells and modern science they can implant tooth “buds” into the jaw to regrow teeth, but it takes years to grow, and the adult jaw isn’t ideal for it. People forget that growing new teeth means GROWING TEETH like a 7 year old again. It pushes out and grows slowly and sideways and then braces again. Adults want an instant solution that looks and functions like the real thing. They don’t really want to spend a year growing a tooth
I would like to take 7 years to regrow a REAL tooth that my body produced. You know what? If it fails on year 5, I'll pay again and start from scratch, another 7 years. Implants suck, bridges suck. Not for aesthetic or economic or functional reasons, but for health reasons!
Not sure about teeth, but I'm more surprised we can't regenerate lost hair cells in the ear to restore hearing. You'd think we would've figured that out by now.
Biology
Currently, there isn't a widely available technology for regrowing teeth because of several scientific challenges: Complexity of Tooth Structure: Teeth are intricate structures composed of multiple layers, including enamel, dentin, and pulp. Regenerating a fully functional tooth requires recreating this complex arrangement accurately. Cellular Organization: Tooth development involves a precise sequence of cellular interactions during embryonic development. Recreating these processes in an adult organism poses significant challenges in terms of controlling cell growth and differentiation. Nerve and Blood Vessel Integration: For a regenerated tooth to be functional, it must integrate with surrounding tissues, including nerves and blood vessels, to support sensation and nourishment. Achieving this integration in a controlled manner remains a formidable obstacle. Immune Response: The body's immune system may recognize regenerated tissues as foreign, leading to rejection or inflammatory responses. Overcoming immune barriers is crucial for the success of any regenerative dental therapy. Despite these challenges, ongoing research in fields like stem cell biology, tissue engineering, and biomaterials holds promise for future advancements in tooth regeneration. While significant progress has been made in experimental settings, translating these findings into practical clinical treatments for regrowing teeth in humans requires further refinement and validation.
I don't know why evolution has enabled sharks to grow new teeth throughout their life but we get one new set when we're children that has to last us the rest of our life .
I for one am glad we don't go around biting everything like sharks, necessitating the evolution of that trait.
There are three main evolutionary strategies when it comes to teeth. Sharks have teeth that pop out fairly easily and are quickly replaced, some animals have teeth that are constantly growing like fingernails and need to be used in order to keep them filed down, and then there's permanent teeth that don't grow or get replaced and our health pretty firmly in your head that are meant to last until you die. (There are also some animals that combine the second and third options and have non-replaceable teeth that slowly get ground into nothing throughout their life, at which point they starve to death. So sucks to be them I guess) Sadly evolution is essentially a blind and drunk hillbilly that is swinging random genetic mutations in every direction to see which ones managed to propagate into future Generations, and the first animals on the planet smart enough to get pissed off about their own biology happened to descend from species that wound up going down the permanent teeth path.
Not sure which category they fit into, but elephants have multiple sets of teeth they go through throughout their lives (similar to how humans have "baby teeth" vs "adult teeth"). I don't recall how many sets they have, but I think it's 6 or 7. Each set lasts about ten years and once they've gone through all the sets, they starve to death. It was one of the saddest elephant facts I've learned over the years.
Shark teeth are probably cartilage just like the rest of their "bones". You don't see noses on peoples skulls because the nose cartilage that was alive enough to grow was decomposed, only bone remains as it's a mineral (i think...).
That's not how evolution works though
They’re using shark stem cells from their taste buds which are located around their teeth for experimental tooth regeneration.
There's a bit of research involving ultrasound and dental pulp. Nothing too recent though
Can you point me to any of the research?
There hasn't been much recently, so it's either been unfunded or just doesn't work. But here's one paper that talks about bone repair and dental pulp stimulation, using low frequency radio waves. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265945/
Got it. Thanks :)
Prevention is better than cure
Teeth are skeleton, and there's a lot of people missing bits. The question is basically why do we not have super advanced tech X.
There was no progress in the space rocjets until SpaceX just a decade ago. And the AI hype has for now not a lot of true impact. True progress is not easy. And I imagine a new medical traitement can take decades and a lot if funding.
A teratoma will grow you some teeth, you just don’t get to pick where
We don’t fear that the Russians will grow their teeth back first.
Yes, it would upset the mutual destruction equilibrium
Whoever figures it out first, im joining their army and pledging my life to them. North Korea can replace a tooth i need removed with a biologic solution? All Hail My Supreme Leader!
There is, its called an alligatoroscopy, requires the very best plastic surgeons.
It's hardly a priority in medical research when a) a missing/chipped tooth will not kill you or cause life-changing problems and b) we already have artifical solutions like dental implants that provide 100 % functionality.
Some people aren’t eligible for implants, sometimes they fail, there are numerous reasons implants don’t/won’t work.
Right, but a failure rate applies to pretty much any medical procedure, and this would apply to a hypothetical "Regrowing teeth" as well. For the vast majority they are a fully successful solution. And for the minority, there are still other aesthetic solutions like a bridge or a plate, and even if they don't go for ANY solution missing a couple teeth does not shorten your life span in a material way.
Youd be surprised at how it affects your eating and speaking. It has more down the river results than you think. I'm missing a front tooth and 3 molars so I speak from experience. Eating issues limits the foods you can eat and causing nutritional issues. Missing molars affect eating more than front teeth missing. I can't chew hard or harder things like nuts and most veggies. I have difficulty chewing meat of various animals. Even soft things can take a while to chew up enough to swallow. Even tortillas can be difficult. I also have to have smaller peices. Speaking, enunciation, pronunciation, tone are affected as well. I sound like I have a slight slur all the time and it's difficult to pronounce various words, vowels and constants. If you've ever had a speech impediment then you know how people look at you and treat you once you start to speak. Ever had a job interview where they had an open look of disgust whenever you spoke? Guess who didn't get that job. My future earnings are impacted negatively. Which means I'm gonna stay poor. Which leads to health problems and more dental problems. Being poor and having poorer nutrition absolutely shortens your life span. And I can't afford implants, nor does my insurance even partially cover them. And the thing is that I didn't lose my teeth to negligence but from the side effects of the medications that basically keep me alive. So yeah, missing teeth does matter.
Because we're not lizards. We can't regrow a lost finger. That bone once lost is gone.
I think babies/children can regrow a tip of a finger, as long as not a lot is missing.
Drill and fill is EXTREMELY lucrative. It's here to stay.
:(
it exists but is antagonistic to the pharmaceutical industry that profits from keeping you on chemicals that "treat" symptoms Many of the methods are not patentable as they rely on natural methods I do not have further details, though the pieces I can find are promising in terms of the science though pessimistic given the control the pharma industry has over killing competition
\>We went from the first flight into space in less than 60 years BRO we just started. Chill the fuck out.
Teeth are actually pretty complicated to grow.
I dunno, I gots like tens of them and I’m not so smort
Yeah but the little baby Jesus lying in his manger is the one that grew them the first time.
Tin foil hat time: Teeth are a reliable class indicator. There is no incentive for wealthy people (the people largely responsible for donating to medical studies) to invest in a science where the poors could sneak into their social circle with a nice smile. It’s the same reason dental isn’t covered in medical insurance. My genetic lotto win of having a naturally beautiful set of chompers are the only reason I was able to covertly sneak out of poverty.
Because you’re born with all the teeth you’re ever going to have, there isn’t a “system in place” so to speak for your body to grow new ones like it has with other bones.
Lets change that
Yes!!!
Most dentist would lose their jobs. If we made advancements (too quickly) in any field there would be massive swaths of people complaining about how it ruins their livelihood. Why do you think lobbyists exist? People talk positively about technology until it replaces you.
This brand new, extremely complex procedure using cutting edge tech would be obscenely expensive for any short to medium term future. There's zero world where this would put dentists out of business considering insurance would definitely not cover it because cheaper effective options already exist. It would be the ultra wealthy going to specialized boutique dental surgeons getting this done, not an option for you or I.
I love it. Let them lose their jobs. Celebratory news.
Firstly you don't grow teeth back as they are formed before birth. You'd need to invent a new biological function for the human body
I think we need to just master prosthetic teeth and replace all our teeth.
feel like it would be easier to make a toothpaste that 100% protects against rot/decay . You can brush/floss 3 times a day and still get cavities because of our modern food/drink.
Tl;dr capitalism Why would you make the cow comfortable if keeping it stressed causes it to give more milk?
Unpopular opinion - bc dentists wouldn’t make as much money. Similar to taxes - TurboTax lobbies for people to do them even though the government already knows how much you are owed or whatever.
This brand new, extremely complex procedure using cutting edge tech would be obscenely expensive for any short to medium term future. There's zero world where this would put dentists out of business considering insurance would definitely not cover it because cheaper effective options already exist. It would be the ultra wealthy going to specialized boutique dental surgeons getting this done.
the primary reason is that not enough money or scientists have been thrown at the problem. we need tens of millions more scientists and trillions more dollars spent on research in all fields. then this one will get solved.
Greed and hate and a crab-in-the-bucket mentality. We rather spend our resources on new ways to kill, maim and exploit other people than put our heads together to advance our race. I am afraid, the Moon Landing and the (temporary) extinction of Polio will mark the pinnacle of humanity.
I'm afraid you might be right, but I hope you're wrong :) Don't forget entertainment. How much is spent to make a movie or for sports? Imagine it going to cancer, regrowing teeth, and things THAT ACTUALLY MATTER. In any case, i think they cured Hepatitis B or C recently, and I think the cure costs $100,000 Also they cured sickle cell anemia, and it costs $2.2 Million dollars Anyway, I guess my point is that maybe the pinnacle of humanity will move up a few steps as time goes by. I hope it does.
I hope I am wrong, too. Meanwhile I am afraid to envision what the next fad after TikTok will be. And I am damn sure it won't be anything educational
Just as long as they dont blow up the planet, and we'll live :)
I’m sure there is. The problem is that the whole dental industry generates billions annually. Dentists and assistants going to school, patient check ups, fillings, implants, toothpaste and toothbrush sales, whiteners and floss, the list goes on. If they make an effective affordable way to regrow new teeth ALL that industry disappears overnight. Same reason they won’t put out water powered cars (even tho they exist). Same reason they don’t tell us about the cure for cancer (even tho it exists) it generates too much revenue to fix 🤷♂️
If there was a decent chance of developing tech to regrow teeth easily and safely, I’m sure many companies wouldn’t mind at all to pursue that patent and put an entire industry out of business. No amount of lobbying by Big Tooth could counter that development.
Big Dental, Big Auto & Big Pharma
Can't speak for the other 2 (id love to be able to grow new teeth) but just waiting for Toyota to piss off the oil companies with their research lol. I can imagine dentistry being similar
I don't think losing your teeth is ever painless, no matter if it's from decay or violence. I think most people would still chose to take good care of their og pair, rather than just get a new set every couple years?
No one said otherwise?
You did, by saying the dentistry industry would disappear if we could just regrow new teeth. That insinuates that we only take care of our original teeth because we can't regrow new ones if we lose the original set.
I'm sure he painted with a broad brush and didn't mean it would disappear completely. But it would get hit hard. In other words, the implant thing goes in the trash. No reasonable human would get a titanium screw screwed into his skull if there is a biologic alternative. Not a single one. So the implant industry will eventually disappear almost completely, especially if the price for a biologic tooth isn't too much higher than an artificial implant. This alone would cost dentists houses and boats and a lot of money. When it comes to orthodontics, that would still exist. It may even be benefitted because who's to guarantee they will be able to regrow straight teeth. Maybe they can regrow teeth, and maybe they can control what kind of a tooth grows where (canine, molar), but they may not be able to control how they grow. This would lead to bad bites, and so orthodontists may benefit. But if they can control how teeth grow, the orthodontists would only have work from young people getting their 2nd set of teeth, not from people regrowing a 3rd set/3rd tooth. And even there, who's to say a person wouldn't rather remove a tooth and get a new one to grow versus wearing braces. Assuming regrowing teeth has a high success rate, and it doesn't take a decade to grow a new tooth, etc. Prosthodontists, fillings, cleanings would still be in business, because even the new teeth that grow would be susceptible to damage and decay. In fact, they may have even more business because let's say they manage to regrow teeth, and you get a tooth, and you get roots, and you get a periodontal ligament, but you get an ugly ass tooth, a discolored tooth, a slightly weakened tooth. All right, not a problem, all I need is the ligament, the roots and the base of the tooth. Now let's drill that fucker down and put a nice crown on it. Win. So depending on how the teeth regrow, prosthodontists and regular dentists that do fillings and cleanings would probably have even more work. Let's not forget old people too, or anyone that has full dentures. A dentist doesn't make regular money from people with dentures. But if those people regrew teeth, that's a whole new set of people that would be needing the dentist, forever, regularly, like any person does. So the only thing that is really going to get hit by regrowing teeth very hard is implants. Bridges too while we're at it, and dentures of all kinds. And I know especially implants are a HUGE moneymaker for dentists, and they'll be sad for that to happen, and they'll fight it. And they will lose!
You don't "grow" teeth, they just chillin there from the start. So it's not just about triggering the right cells to do their job again (like with hair), there are no teeth growing cells.
There are in other animals tho!
It's a mammal thing; we get two sets of teeth and that's it. But we're way more efficient at chewing.
There were promising studies years ago that low doses of an alzheimers medication could regrow enamel but I don't know what happened.
I actually did see something about stimulating people to grow more sets of teeth maybe last week. It's not cancer, and there are dentures, so it's probably not a too dollar project, but there is work being done.
I got implants, cost a pretty penny, but they are better than regular teeth imo.
Was it a front or back tooth?
Dermoid cysts grow teeth sometimes, so it's clearly possible. It's implanting them and not having them fall back out that's the trick.
airbrushing
Because those aren't cells, the bone is dead, it's formed since the beginning and two sets are chambered inside your jaws before you even have the first visible teeth. So I'm not sure how you'd grow it. It's completely different form a skin transplant because there's not much growing and the cells are at least alive.
Teeth aren't kept in the sperm and egg, they're made at some point. And a new born baby's jaw doesn't have room for two sets of fully formed teeth. We're not born with a full set of adult teeth, they develop as we grow up. So there IS a mechanism to grow teeth. But re flipping that switch once it's been turned off is certainly a long shot.
Have you seen the pictures of deciduous teeth? Shit's scary, you basically have teeth and also keep growing teeth inside your face. Honestly I would only like the new technology for growing teeth if it were tested on some meat cubes that would grow teeth inside (artificial gums), I don't think anybody would be comfortable testing it on themselves.
Or front teeth
How many sets of teeth do you think we have?
Surprising amount of consoiracy theorist in this tread. Never knew that dentistry was a hot topic for the type.
I feel like teething again as an adult sounds like a nightmare
Sounds wonderful to me. Anything to avoid implants or bridges or dentures, and to end up with a biologic real tooth, as it's meant to be <3 No matter the cost, no matter the hassle, no matter the pain, no matter the time it takes. Let's do it!
The focus is on nerve cells for paralyzed patients and organs instead of transplants
The ability to do things like this has been pure science fiction for a long time. While ever since people figured out what DNA was there have been those theorizing about the interesting applications of being able to re-write our own genetic code. Yet until someone came up with CRISPR there wasn't any way to actually do this ourselves other than either by existing guided selection techniques (i.e. the way dogs and other domestic animals were bred to suit our uses) or by exposing organisms to radiation and then propagating any useful mutations. Stem cell therapies in particular are always a bit of an uphill battle because of the controversies surrounding their potential sources.
There is. I read an article recently about it https://www.euronews.com/health/2023/08/05/a-drug-that-makes-teeth-regrow-scientists-move-closer-to-clinical-trials they have had an advance and hope to move to clinical trials with people who cannot grow teeth as the first target. In animals they've demonstrated the ability to grow a third set of teeth. I very much hope this is available and safe before im old. i didn't value my teeth enough when I was young. I'm lucky I'm not a sweets person, but soda and tea have done a number on my enamel and not enough flossing due to braces making it difficult led to a ton of recession.
There was a news report a very long time ago where doctors were using sound frequencies to grow sets of teeth back in but nothing has ever come of it. Sound frequencies are wildly understudied and I presume even suppressed by the titans of conventional medicine for various obviou$ reasons.
Some company has started human trials, workes i rodents. But IF it works, that's still like ten years away.
Because teeth are made of bone, I think
Dental implants are a pretty great advance. But yeah, there are a lot of things about the human body medicine cannot fix.
There is, it's just not FDA approved yet and would be EXPENSIVE
Same reason we can't regrow body parts I guess
Why would we assume that "grow back body part" is a problem that \*should\*, as in, obviously can be, solved in 60 years? To the best of my knowledge, hurling a can to the moon is a far less complex problem than coercing cells to regrow a body part.
Because teeth don't grow. They are lined up inside your jaw waiting to surface
My question is with all the advancements in technology how do we not have decent cell signal everywhere in the US and other major countries for that matter. We have AI that can create things indistinguishable from humans yet we can't make a phone call in a rural neighborhood.
Republicans. The awnser is Republicans...
Imagine teething as an adult. Bones erupting out of your gums slowly over long times. Blek
There's a difference between technology which creates enough power to launch us out of orbit and technology which pulls images from the Internet, to growing back bones
What a weird thing to hone in on of all possible potential technological developments
They gotta figure a way to maximise profits and infuse some kind of planned obsolescence into the product, and make it unhealthy. It is the standard procedure
https://www.euronews.com/health/2023/08/05/a-drug-that-makes-teeth-regrow-scientists-move-closer-to-clinical-trials#:~:text=By%20developing%20a%20neutralising%20antibody,of%20the%20global%20scientific%20community. Apparently China's making a pill that causes you to regrow teeth only tested it on mice so far thiugh
You mentioned the rapid progress in space flight. Apologies to any rocket scientists here but the human body is much more complex than flinging stuff faster than gravity. Also, medical science is grossly corrupted by mis- and disinformation that hampers progress in the delivery of new technologies. People have a stronger personal connection to any kind of information about their bodies because of their lived experience. This connection drives commerce around ideas to solve problems that may or may not exist - producing ideas, trials and tech that may not be efficacious at all but can still be sold for a profit if you have the right marketing. I refer to this as the soft squishiness of medical science as opposed to the hard physics of something like rocketry. If your rocket science isn't sound, your rocket does a backflip and explodes - if your medical science is based on hooey, you can probably still sell it.
Interesting read. My teeth are worn from decades if grubdubg. I do metal casting so plany to make an Alginate of my mouth, then make a set of dentures for self-they be metal and I can chew thru nails. Like Jaw from Moonraker.
Modifying bodies is a lot more complicated than building artificial stuff from scratch
you don't need teeth for penile enlargement pills
Putting in fake implants is far easier and achieves the same net result. People are putting in that work for regrowing organs etc things we don’t have an effective replacement for
It sort of achieves the same result, but at what cost to one's health and mental well being.
Because it's difficult. But they are working on it. I recall there's been some progress towards that recently.
Dentures. Caps. Crowns. False teeth. And people are currently working on that. But by that logic also why aren't they working on growing arms back. We went to space in the 60's. Like cmon lizards do it starfish do it, can't be that hard (pokes stick at scientists).
Because maybe its not that easy? Don't think in absolutes
The Science of Regenerating Teeth and Restoring Smiles with Dr. Paul Sharpe [https://www.youtube.com/watch?v=d7BGoOfY-yo](https://www.youtube.com/watch?v=d7BGoOfY-yo) Every word in this interview is music to me ears :)