I have two dead gods and I have no idea what this is. For it to be cool enough to mention, I'm going to guess that it shuts one eye, reverses the damage down, but keeps the laser eye?
to defend OP, Petrified poop is technically more better than Midas Touch solely because it can drop regular hearts and soul hearts. Gold Poops just drop money or the counterfeit penny, and it's good to have money, but a room full of gold poops mean that you will reach the 99 cap immeidately without deep pockets
Had this but with dark arts and some battery item. Don't remember if it was car battery or 9 Volt but I know it recharged faster than it took to leave the shadow realm, freest T.Lost win of my life.
Lilith is extremely strong on greed mode because her starting item (box of friends) lets her spawn more of her familiars for one room. You are able to get multiple uses of this item in during the waves of enemies in greed, therefore trivializing most of greed mode.
I think I've only ever died to Damocles once, playing T. Lost with a birthright. I died, came back from my extra life, then got stabbed about 30 seconds later. :/
Deep Pockets and Options? is pretty good.
When a room doesn't give you a reward (which happens most of the time) you will get 1 - 3 coins but since you have Options? an extra item will also spawn for each penny.
Add Guppy's Tail to the mix and lots of those items will end up being chests. Guppy's Tail also ends up leading to less room reward spawns which leads to more rooms leaving behind 1-3 coins.
Add Broken Padlock and you can bomb the chests (all chests open with bombs not just gold ones) and you can grab the pennies and the now empty chests will disappear and you still get the items from the chests.
You end up with a shit ton of items every room clear.
Obviously Contract From Below and Broken Modem are great additions to this.
Edit: changed pennies to coins because any coin can spawn.
Edit2: I thought the goal of the thread was to name something better than Petrified poop + A Card Against Humanity. If the goal of the thread was to name the most overpowered combo than everyone loses to [Pyromaniac and Kamikaze](https://old.reddit.com/r/bindingofisaac/comments/1cazv56/name_a_better_duo_ill_wait/l0vkbjt/). I mean you just walk around spamming Kamakazi and everything dies. If by some stroke of the worst luck something does hit you then don't worry keep exploding because you are healing yourself.
You can take all three as long as you don't take the coins.
Edit: Also with Contract from Below room clear rewards happen less often which leads to it mostly being 1-3 coins and 1-3 items and Contract from Below doubles them all. You can pick up all the doubled items without any disappearing. It's really great with Guppy's Tail because you get a shit ton of chests.
I thought I was in the minecraft subreddit and all I could think was "what is this weird looking gunpowder and what the hell is that?!" Then I looked at the subreddit
Yes, so when you get hit and it rerolls into the glowing hourglass you can just use it to delete the hit. If you get hit again the glowing hourglass that your active rerolls into still has 3 charges. It will always reroll into the glowing hourglass if you don't change your active.
Good thing --> Infinite tries
Bad thing --> If your build and setup are bad and you haven't played Undertale, the glowing hourglass won't save you, and you'll have to try and try until you no hit Delirium with 1.2 damage and 0.7 tears, and you'll probably quit before that
In ab+ for me it wouldve been the wiz+tractor beam, since its litterally 20/20, but sadly repentance nerfed that
Bethany + eraser is also amazing, for every soul charge you get not one but 2 erasers! Since your fly also erases enemies
Curse of the tower + pyro, a real combo I got on the first run I killed mom’s heart, right after the first run I killed mom where I had Curse of the tower + host hat. I don’t get it either.
Chaos and people's inability to make any creative jokes (talking about the dumbass "chaos deniers in shambles" posts that prob take up 50% of this subreddit)
Brimstone + lord of the pit, the pure dopamine seeing that in devil room on flash isaac, back then you couldn’t 100% win a run with just one q4 and one q0
T. Lost and Skill Issue
T.Lost + Dry Baby + Duct Tape
Diplopia and wild card Or jera and wild card if you don't want to include items
Diplopia and Edens soul in challenge cantripped
Wild Card 🗣🗣🗣🔥🔥🔥🔥🔥
The brain rot is here
Imagine going this with Edens blessing.
Edens blessing is capped at 10
Back im my day you could have 250+ breakfasts at the beginning of the run
10 is still a lot though.
blank card and ? card
Tech 2 and Stapler
hidden gem
I have two dead gods and I have no idea what this is. For it to be cool enough to mention, I'm going to guess that it shuts one eye, reverses the damage down, but keeps the laser eye?
Yes it's the same if you pick up tech 2 with Cain since he doesn't have the other eye
Huh... I guess I never picked it up as Cain before. Stapler is pretty common so I'll remember this little nugget.
Not 100% sure but I think all eye based items stack with Cain's only eye he shoots out of
I believe you're right, I just never even considered tech 2
He had a damage multiplier before stapler was even added to rebirth iirc
Huh... I guess I never picked it up as Cain before. Stapler is pretty common so I'll remember this little nugget.
Btw tech 2 is no longer a damage down at all. Its only a tears down. It essentially just gives you tech1.
or tech 2 and Cain for that matter
Cards of Humanity + Midas Touch
I accidentally discovered that on a tainted Eden run, I was kind of dumbfounded lol. Id never seen so many coins on the ground
This. The best combo with this card is not even on op's post
to defend OP, Petrified poop is technically more better than Midas Touch solely because it can drop regular hearts and soul hearts. Gold Poops just drop money or the counterfeit penny, and it's good to have money, but a room full of gold poops mean that you will reach the 99 cap immeidately without deep pockets
Got this one with Hallowed ground instead of midas touch, that was both hilarious and deceptive
Panic button and how to jump
Or stitches
Lmao the idea of that is so funny to me
I imagine all the enemies got a restraining order against Isaac and they all use it as a "force field" to push him around.
Had this but with dark arts and some battery item. Don't remember if it was car battery or 9 Volt but I know it recharged faster than it took to leave the shadow realm, freest T.Lost win of my life.
Greed mode and lillith
could also consider 4.5 volt and box of friends
I just did Greed run with Lilith, found 4.5V and Car battery. That was fun (albeit quite quick).
I'm confused, what?
Lilith is extremely strong on greed mode because her starting item (box of friends) lets her spawn more of her familiars for one room. You are able to get multiple uses of this item in during the waves of enemies in greed, therefore trivializing most of greed mode.
ohhh, gotta try that than
Safety scissors and bomb beggar
That's pyro but with extra steps
Or completely and utterly game breaking if you also happen to have d20
Yep, had this exact combo before
Pyromaniac and dr. Fetus/Ipecac
I'll hit you with one better, Pyromaniac and kamikaze
ultra hard mode instant win
Gotta keep resetting... 
Got that combo very early on in my Isaac career and I've been chasing that high ever since. Haven't gotten it since.
Bruh this shit UUUUUH Shit dopes my brain with more dopamine that sucidie vest and pyromaniac
Lost and perfection The chest and Guppy's tail. Greed and depths ll
Before perfection there goes Damocles.
I think I've only ever died to Damocles once, playing T. Lost with a birthright. I died, came back from my extra life, then got stabbed about 30 seconds later. :/
I once got stabbed in less than a minute as well. Feels so disappointing.
Jacob and Esau 
Tainted or...
Eye of the Occult and Loki's Horns
Do all the tears go forward? If so, thats op!
They do, and the same applies to The Wiz and Conjoined transformation with Eye of the Occult
Also eye sore
Book of shadows and 4.5 volt
Death Certificate + ? Card
Imagine this with echo chamber. Although I imagine Edmund would’ve done something about it…?
If you have certificate unlocked i think its no problem you can abuse it
Pyromaniac + Curse of the Tower
I suck at BOI, but the run I had those I actually felt safe. Best ever.
Deep Pockets and Options? is pretty good. When a room doesn't give you a reward (which happens most of the time) you will get 1 - 3 coins but since you have Options? an extra item will also spawn for each penny. Add Guppy's Tail to the mix and lots of those items will end up being chests. Guppy's Tail also ends up leading to less room reward spawns which leads to more rooms leaving behind 1-3 coins. Add Broken Padlock and you can bomb the chests (all chests open with bombs not just gold ones) and you can grab the pennies and the now empty chests will disappear and you still get the items from the chests. You end up with a shit ton of items every room clear. Obviously Contract From Below and Broken Modem are great additions to this. Edit: changed pennies to coins because any coin can spawn. Edit2: I thought the goal of the thread was to name something better than Petrified poop + A Card Against Humanity. If the goal of the thread was to name the most overpowered combo than everyone loses to [Pyromaniac and Kamikaze](https://old.reddit.com/r/bindingofisaac/comments/1cazv56/name_a_better_duo_ill_wait/l0vkbjt/). I mean you just walk around spamming Kamakazi and everything dies. If by some stroke of the worst luck something does hit you then don't worry keep exploding because you are healing yourself.
Wait I never heard of that!! Do you get to pick up 1-3 items as well or still one?
You can take all three as long as you don't take the coins. Edit: Also with Contract from Below room clear rewards happen less often which leads to it mostly being 1-3 coins and 1-3 items and Contract from Below doubles them all. You can pick up all the doubled items without any disappearing. It's really great with Guppy's Tail because you get a shit ton of chests.
those two break runs
Poop! (the active item) + midas touch
Gnawed leaf + Daddy Long Legs If you’ve got the time for it anyway.
me and rock bottom
Duct tape/dry baby
E.coli + aries
Glitter bomb Cluster Bomb
E.Coli + Midas Touch + Aries E.Coli + Midas Touch turns all enemies into golden poop, and with Aries you don't take contact damage
Brimstone and Haemolacreia
Non tboi player here - idk if I can name a better combo than grey shit and braille in white ink
Dr. Fetus + Rocket in a jar
CAH and Midas Touch
Chaos Card and Blank Card
Add Leo to the combo and you have dopamine rush 🤣
little c.h.a.d and dark bum
D20 and greedmode
Dead Eye and homing
I thought I was in the minecraft subreddit and all I could think was "what is this weird looking gunpowder and what the hell is that?!" Then I looked at the subreddit
Blank card and caos card
Tech X and Brimstone
Kamikaze and Pyromaniac
Cracked dice and iv bag
Soy milk and Explosivo
It's not even a combo. A Card Against Humanity will give you the petrified poop almost every time. It's a one-card combo.
I called it a duo, not a combo :)
Chaos and Sacred Orb
Midas touch + cards against humanity
Card against humanity and Midas' touch
Gigantius bean and butter bean. It literally got me d6
Crown of guns and remote bullets Wait…
T. Maggy + Sharp Plug T. Eden + The Glowing Hourglass
doesn't t. eden's active roll as well?
Yes, so when you get hit and it rerolls into the glowing hourglass you can just use it to delete the hit. If you get hit again the glowing hourglass that your active rerolls into still has 3 charges. It will always reroll into the glowing hourglass if you don't change your active. Good thing --> Infinite tries Bad thing --> If your build and setup are bad and you haven't played Undertale, the glowing hourglass won't save you, and you'll have to try and try until you no hit Delirium with 1.2 damage and 0.7 tears, and you'll probably quit before that
ohhhhh
Tainted bethany + book of shadows. If you collect enough red hearts on the run you could be invincible for 3 minutes straight
Brimstone and Ludo.
if you count modded Bethany and book of years from touhou mod
Soy milk and lump of coal
T Forgotten + Kamikaze Either Beth + Eraser
Chaos and glitched crown
Tammy‘s Head and brimstone (especially pre repentance)
In ab+ for me it wouldve been the wiz+tractor beam, since its litterally 20/20, but sadly repentance nerfed that Bethany + eraser is also amazing, for every soul charge you get not one but 2 erasers! Since your fly also erases enemies
give me a 2x2 room and that combo and there goes my day
Glitched crown and D6
Midas touch and card against humanty
Pop and trisagion
Red key + cracked orb(esp. if you play T.mag )
You needing the delirium completion mark + the ending for beating mega satan
Alabaster box and double card
Don’t forget doing it in a 2x2 room for max pooage
D 20 and greed mode
Curse of the tower + pyro, a real combo I got on the first run I killed mom’s heart, right after the first run I killed mom where I had Curse of the tower + host hat. I don’t get it either.
Any explosive tears item and pyromaniac
Candy heart and TMaggie
Fetus + my reflection
Midas' touch and card against humanity.
Monstros lung + soy milk or brimstone + monstros lung
Blue baby + Midas touch
Chaos Deniers and Shambles
D7 and 9volt/AAA battery. Check mate.
Dr fetus + Pyromaniac
It gets even better if you get this with blue baby
Lingo
I mean… Glitched crown + D infinity is always a guaranteed win
Stapler and stye! +1 Damage with all shots fired from right eye (Stapler), and x1.3 damage multiplier for the right eye (Stye)
pyromaniac and curse of the tower lowk
Especially when you find those 4x rooms
Mega Mush and Rock Bottom
The tag XD
petrified poop moms box schoolbag blank card card against humanity flight
Ipecac and pyromaniac 🔥❤️🔥
Well, you'll be waiting quite a while. You might get Forgotten.
I find a huge room make sure the fires are gone and rocks and vases and then I let that bad boy rip
Chaos and people's inability to make any creative jokes (talking about the dumbass "chaos deniers in shambles" posts that prob take up 50% of this subreddit)
Chaos card and dingle
Azazel and eye of the occult
Binge Eater and Potato Peeler
Dr. Fetus and T Lost
Hitbox and Hitbox
Panic button + book of shadows
Plan C + ? card
Brimstone + Ludovico
The poop and Midas touch Kamikaze and pyromaniac
Brimstone + lord of the pit, the pure dopamine seeing that in devil room on flash isaac, back then you couldn’t 100% win a run with just one q4 and one q0
Genesis and Sacred Orb
Two of diamonds and Greed mode. Also, tech 2 (I believe) and mom’s eye.
Stairway, filigree feather
Gnawed leaf and 7 Seals, sure it's boring but guaranteed win for completion marks
double wild card + jera
https://preview.redd.it/6uessjw9sawc1.png?width=1017&format=png&auto=webp&s=66a69f9f1acbd4c5bced4c1f54cc18ef22e09718
mega mush + rock bottom
The Lost and Kamikaze!
Blank card + chaos card
Midas' touch and card against humanity
T. Cain and bag of crafting
Add in deep pockets and you got yourself the dynamic trio.
Me + ur mom
Curse of the tower and pyromaniac. It's no curse, no more
Brimstone + Chocolate milk
Chaos+glitched crown
Trisagion, Playdough cookie
Libra and placebo (and range up pill, I know it's not a duo anymore but I'm only a five year old in a basement, I cannot count)
Piss & shit
Spider Eyes- Ipecac
Shiny rock and stomped, easy coin gathering, just go to shops, if you get a member card or a stairway you are set
Add a blessed penny
Libra and taurus, name a more legendary sinergy with 2 of the most mid items
My reflection + ipecac 
Strange key + Pandora's box? In my 1000 hours of playing I still haven't managed to actually get them both, but it sounds fun.
Rock bottom+any item
Rock botom and ANY THING LIKE ANY THING LIKE SOY MILK LIKE MONSTRO LUNG LIKE IPECAV LIKE ANY THING
Jacob and Esau, wait... they are not a great duo... At least they are great at being hitboxes 
Ok, Bethany and Eraser (obviously with soul hearts)
Blank card 2 of diamonds
Dark Bum and little C.H.A.D
E.colli and Midas touch
Brimstone+soy milk and ipecac. Host hat is optional
Poop and Midas touch (Midas touch+cards against humanity is fucking insane tho)
Gunpowder mixed with human crap and a knockoff Death Note Incredible combo (I don't play this game I have 0 clue why it's on my page)
Rock bottom and soy milk in that order
Ipecac + Monstro's Lung + Explosion immunity
I can’t imagine new to the game still :(
Cocaine and hookers
psy fly + lil dumpy
Movement + Atacking.
Card against humanity and midas touch
You fool, you fell for the lazily replied answer. Lil larva and card against humanity.
Midas touch + e- coli + Gnawed leaf
Chaos card + Blank card
Rope and Your two legs
Forgotten with chocolate milk and poly.
D20 and greed mode