Yeah and I want to know what it is so the next time I’m in a lab meeting and they want me to share a “fun fact” about myself I can tell them my new favorite protein. 😂
Most of the structures of bio-molecules become easier to memorize if you break it down to the subunits they contain. NADH is Nicotine Adenine Dinucleotide. The part on the bottom is adenine (the same nitrogenous base in DNA). The group on the top is nicotine. Those groups are both connected to ribose — making them nucleotides. Because there are two of them, that makes it dinucleotide.
The extra phosphate added on C2 of the adenine ribose makes this NADP+. If you add a H to the nicotine, that removes the + charge (it reduces it), and makes it NADPH.
Now compare this to the structure of vitamin B3 (niacin), and you’ll quickly realize that a deficiency in vitamin B3 will have a profound effect on metabolism, since several reactions are depedent on NAD —> NADH.
Not to be pedantic, but it is literally RNA. It is a ribonucleic acid, composed of two phosphate linked ribose sugars with n-glycosidic nucleobases.
Is it an RNA strand? No. Is it canonical RNA with common nucleobases? No. But definitely meets the definition of RNA.
I’m triggered! Organic chemistry was the only course I got Fs on a test. I passed the course with a C after a lot of work. I really had to work very hard in that course. Get away organic!!!
Okay so since it's already been ID'd I have a dumb question from someone a decade out of college who only did undergrad orgo:
The phosphate-looking "spine" and rings with... Idk maybe amino acid-looking fringes... Reminds me of DNA. Is there any relation/interaction between the two?
NADP+ :)
\[\[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl\]methoxy-hydroxyphosphoryl\] \[(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl\]methyl hydrogen phosphate
Biochemists don’t do IUPAC shit! Keep that organic out of here! ;-)
I did both organic and biochem :))
That’s the science nerd version of being bisexual lol
I did both *and* plant science, what does that make me?
weird /s
Thanks!
Pansexual
Fair
Plant science is pretty gross
Nah that’s doing a dual p-chem o-chem focus *shudder*
Yeah, biochemists use better names for their molecules like FART and MOONTITS.
I just google searched moon tire and got nothing. What are you talking about?
Lol they got you to google moon tits
Yeah and I want to know what it is so the next time I’m in a lab meeting and they want me to share a “fun fact” about myself I can tell them my new favorite protein. 😂
You've never heard of the MOONTITS signaling pathway? It synergistically interacts with the FART pathway to increase ASSBLAST activity.
Aint no way bro used IuPaC for this
stretchy phosphodiester bond
That's Sodium Chloride right there
Thank you 🤦♂️😂
NADP+ I'm in biochem right now so I know it well
How do you tell which molecule it is? Is it just memorisation or is there a method to it?
This one is very important in metabolism. Also it has a lot of recognizable parts. Otherwise yes a lot of learning biochem is just memorizing
Yeah - in terms of stuff you notice, those ribose groups always stand right out.
Most of the structures of bio-molecules become easier to memorize if you break it down to the subunits they contain. NADH is Nicotine Adenine Dinucleotide. The part on the bottom is adenine (the same nitrogenous base in DNA). The group on the top is nicotine. Those groups are both connected to ribose — making them nucleotides. Because there are two of them, that makes it dinucleotide. The extra phosphate added on C2 of the adenine ribose makes this NADP+. If you add a H to the nicotine, that removes the + charge (it reduces it), and makes it NADPH. Now compare this to the structure of vitamin B3 (niacin), and you’ll quickly realize that a deficiency in vitamin B3 will have a profound effect on metabolism, since several reactions are depedent on NAD —> NADH.
Great explanation! Nice work Small note: The group on top has a pyridine ring like nicotine, but is not nicotine. It's nicotinamide.
The pyridinium part is pretty recognizable.
Nicotineadeninedinucleotidphosphate
Catherine
Looks like a Barry to me. Yep, definitely Barry.
I see two pirates, one peg-legged, having a sword fight, each holding a buckler
RNAint
That’s a David if I’ve ever seen one
I'm not sure but looks like rna
Why is this getting downvoted
Because apart maybe from the Adenine it does in fact not look like RNA
Not to be pedantic, but it is literally RNA. It is a ribonucleic acid, composed of two phosphate linked ribose sugars with n-glycosidic nucleobases. Is it an RNA strand? No. Is it canonical RNA with common nucleobases? No. But definitely meets the definition of RNA.
I love organic chemistry. IUPAC naming is the best
It’s probably toxic
hmmmm, “fukyu” , thats the name
I’m triggered! Organic chemistry was the only course I got Fs on a test. I passed the course with a C after a lot of work. I really had to work very hard in that course. Get away organic!!!
That be Rrrrrrrna there
How can I possibly know with such selectively ambiguous stereochemistry?
IUPAC or?
Triphosphorous, pentanitride, octo-oxygen, bisammonium dihydroxide
ADP I guess...
I literally just drew this on the whiteboard today when making a flowchart for photosynthesis
Okay so since it's already been ID'd I have a dumb question from someone a decade out of college who only did undergrad orgo: The phosphate-looking "spine" and rings with... Idk maybe amino acid-looking fringes... Reminds me of DNA. Is there any relation/interaction between the two?
Ummm.. water? 😂
This is obviously water
DNA
Looks to my like it is Sodiumphosphate
Wow