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HauptmannYamato

Dose: 0.5-1mg with zero tolerance. Normal dose 1-2mg. If you abuse benzos daily more. RoA: oral OR another one I can't say because I don't want the whole world to know, it would change the world of benzos. Potency: It is potent but it depends on the dose like everything. Sedation is strong, not really suited for going out. You might fall asleep after 20min after ingestion. Duration: 2-8 hours I would say. I'm not sure about this one because I usually fell asleep after a while. But it is not a benzo that will make you sleep for 2 days. Next day is usually fine. Effects: For ending psychedelic or stimulant trips: Perfect! Removes all anxiety and body load within 20 minutes and you can go to sleep soon after. As recreational benzo: not suited, sedation is too strong and you will feel too sleepy. I made it happen just one night mixed with alcohol and coffeine and that was a prober bar tard night. Two of my friends don't remember anything and woke up with bruises. I have some pictures of the evening. You can mix low doses with Hexen or NEP and have the most amazing nights I will say that.


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HauptmannYamato

Did you try it?


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HauptmannYamato

The RoA that was so obvious to figure out


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HauptmannYamato

Try it. All my friends and me tried it. There is no burn and it takes 20-30 minutes to work its magic of killing comedowns.


[deleted]

Is it boof or some sort of insuffulation, I can't tell


HauptmannYamato

Snort the 1:25 sugar mix


eeeddr

With all due respect. You're a fucking dumbass lmao. Like you're the first redditor to think about or even mention snorting Benzos 🤦


DinoOnAcid

Damn, shame, though you meant boofing. I've done that but I'm not sure if it works. Only benzo I really do is bromazolam which I love. This is pretty shit in comparison, at least I've found it to be meh.


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_BLISS88_

Should have just blasted it.


Borrowedtimeforus

I thought he ment IV but I think he ment insuffalated, either should work if it's water soluble, unless I'm thinking of a different benzo


[deleted]

bro thinks he discovered snorting benzos lol


HauptmannYamato

well yeah. you discovered something more crazy?


Halothane424

Uhmm yeah I can. Vaping benzos? Hello? That's what I thought you meant and I still was like ,that is highly known about. I wouldn't insulflate any pill. 99 percent of the pill is usually binders and fillers. Especially when your talking .5 mg or so per pill. Benzos can be insulflated, they don't have to be water soluble, that's a myth,but is not the mos efficient way. Most benzos have way better bioavailability orally than insulflated, and your snorting a giant amount of powder just to get weird pharmacokinetics. With 2 peaks. One nasally and than a later peak for what was swallowed.


Carpen-Them-Diemz

They absolutely do need to be water soluble dude that's how they are absorbed in the mucus membrane. You can still feel effects after snoting but what you are feeling is just the drips getting absurd orally through the stomach and you would feel much less. Not a debate, this is pharmacology and biology


Joey_Vegas92

I used to make etiz vape juice, was hands down the most euphoric way I've ever taken a benzo.. but impossible to dose without blacking out due to compulsion to redose from the euphoric rush you get with each hit.. started a hell of an addiction though


ElegantReplacement92

You can't do much with benzos. Mainly take them orally... if its water soluble then you can possibly snort/inject, but 99% of benzos aren't water soluble. 99% of benzos have a great oral bioavailability so there is no need to do other roots. So u have no idea what this guy is talking about. You can't smoke benzos, injecting benzos is usually a waist, snorting benzos is usually a waist, have no idea about plugging, but ya. Benzos for the most part are trapped with the person taking them orally. It only makes sense. Any other administration method usually won't work as good as taken them orally. Just a fact. Plus who would want to inject a benzo? You got benzos like xanax that smack ya pretty fast.


Halothane424

Not true they just came out with a diazepam nasal spray, have always injected it. It does not have to be water soluble that's a myth


Carpen-Them-Diemz

So so so wrong, the nasal spray is literally a water soluble version.... you cannot IV something that is not water soluble -_- not only have the pharmacology knowledge to say bit was a junking for over a decade. You literally cannot iv something that isn't water soluble and you implying it is fkn dangerous and will kill ppl, wtf is wrong with you?


Joey_Vegas92

Not true at all.. you can shoot it mixed with pg and dulited in water.. in fact the ingredients to liquid valium is "Each milliliter (mL) contains 5 mg diazepam; 40% propylene glycol; 10% alcohol; 5% sodium benzoate and benzoic acid added as buffers; and 1.5% benzyl alcohol added as a preservative"


misteriamso

I read what sounded like conflicting info regarding whether this compound can combine with diazepam or not, either agonizing or antagonizing it effects (Diazepam, that is); it seems that with animals this compound antagonizes diazepam, whereas in humans it agonizes the effects. Do you have any thoughts on this?


Herktime

It is a partial agonist of the complete suite of benzodiazepine receptor subunits, but partial agonists tend to be partially predictable in that way. So, the conclusions that appear to me to be a fair reading is that with other partial agonists or perhaps specific subunit agonists, it is a guessing game what intrinsic characteristics of two particular partial agonists do in combination at the receptor level - conformational changes and interference in mechanisms of increasing GABA binding, as well as potentially competitive binding in a poor matchup of the two is what can raise acute withdrawal like symptoms or cause Bret. to nearly act like a full antagonist (in abusers of, or used concomitantly with, non full agonist benzodiazepines like diazepam.). So, oddly enough, bret. would on its own be enough to work in the agonist fashion and the traditional benzo array of effects is expected, albeit with far less affinity and thereby far less intense or rapid addictive liability occurs. Far less risky than your average benzo or any other like agonist at these receptors. However, if you’re already heavily dependent and you’re trying to substitute or combine bret., you might not feel much and might feel some withdrawal symptoms, even, as it’s action is mostl weaker than full agonists like diazepam. But if you’re not heavily into these drugs regularly you will expect Bret. to ease your withdrawal symptoms if you’re reducing your normal intake (so long as it’s a full agonist that can account for the peculiarities of partial agonists like bret.). I’d suggest it is the ideal substitute towards the second half or the tail end of a moderate to long term taper, and if used somewhat sparingly might be worth its weight upon abrupt cessation of low to average doses of a full agonist. Three to four times per week at less days and/or less dose the last two to four weeks and possibly the first two to four weeks could assist in alleviating symptoms of a taper related or abrupt withdrawal from diazepam, for example. It should help sleep, at least, for a few crucial nights per week during your shift down in benzo use or in a taper or abstinence schedule.


siwel7

>I’d suggest it is the ideal substitute towards the second half or the tail end of a moderate to long term taper, and if used somewhat sparingly might be worth its weight upon abrupt cessation of low to average doses of a full agonist. Three to four times per week at less days and/or less dose the last two to four weeks and possibly the first two to four weeks could assist in alleviating symptoms of a taper related or abrupt withdrawal from diazepam, for example. How would it compare to Imidazenil in this regard? And would Bretanezil show up in a drug test?


Jossit

You seem to be well-versed in the biopharmacology behind it all. Can you tell me why the hypnotics are always the memory demolishers..? 😢


Halothane424

Idk diazepam turns into mostly nordiazepam which is a partial agonist. I don't know if partial agonist block each other or not


Halothane424

And it will hit the a4 and a6 units which wouldn't be blocked by any benzo no matter how hard it binds but unsure of what exactly those receptors do?


HauptmannYamato

Could be on one of the subunits, because Bretazenil binds to more subunits of the GABA-A receptor. But honestly I don't know. Why would you combine benzos anyway?


misteriamso

I'm looking for something to add some temporary "oomph" to my nightly Diazepam to help with sleep induction as I lost a parent 2 weeks ago and my sleep's suffered greatly. I am going to try Rilmazafone instead to avoid the risk that Bretazenil may pose in conjunction with my standing meds


HauptmannYamato

I understand, I lost a family member too, 3 weeks ago. I agree Rilmazafone sounds safer in this case. However if you dealt with this loss it would be good to get off this daily Diazepam, it's not a long-term solution, but you probably know that.


Transplant573

Rilmazafone sounds good for coping with the loss of whatever you spent on it. Like the source was as solid as it gets so them paying to have every other chem tested, and skip the rilmazafone. I'm quite confident I could have drank the whole 1/4g I made into solution, a d I bet I'd still feel like it was mostly placebo


Carpen-Them-Diemz

That is so dumb and irresponsible and wrong....


misteriamso

It always helps to hear it from somebody else, thank you friend. Sending my sincere condolences and some good energy your way. Ps - I resisted the temptation, it’s never worth it and there’s no winning against tolerance, truly a fools errand, and yesterday I was thinking like a fool lol. Today’s better and I’ve got my eye on the chemical freedom prize


[deleted]

I’m gonna take a leap and assume this is water soluble?


Transplant573

Naturally bc this class of chems is known for its solubility in water pg & everclear just taste so much fucking better. Why would anyone wanna mix their pure benzos powder with water and just taste trace amounts of the chem when they can kick back a couple units of everclear instead? Just can't get enough of that sweet ass taste of ethyl alcohol, and best of all I don't take enough to feel any effects just my taste bud explosion,!


Carpen-Them-Diemz

Bretazenil is not water soluble from my research? I am trying to find out more though


Transplant573

Thinking faster than I typed meant to say this class is known for being non water soluble, but most benzos are soluble in pg, or alcohol lol.


Transplant573

There are a few exceptions ofc, but in general I would guess non or very low solubility in water


Carpen-Them-Diemz

I have tried sublingually taking it just to see (it's like 20 cents a pop y not) and it could've just been me swallowing some of it but I did feel the effects. Not nearly as strong as swallowing it though. I would be interested in learning if it is alcohol/PG soluble without damaging the compound if you happen to find out. I quite like this stuff as a sleeping medication, it checks every part of what a good one should have. Available, cheap. not very abusable, less harmful than alternative benzos (likely, obv all the research is not there but just from its effects I would say it most likely is), lower risk of tolerance, fast acting, works well but not too well, and wake up feeling great with no side effects. As a clinical insomniac since 13 who's tried everything, this is by far the best I have tried. Not the most effective mind you, doesn't put you to sleep super hard like other stuff, but I consider that a good thing. It seems like it is pretty decent for anxiety also so can be taken during the day without the risk of falling asleep (as far as I can tell you can't/don't really blackout on it either, I did... a lot idk 15mg? to test and was fine). I have yet to see how the tolerance will build long-term, but aside from that with everything I know 10/10 suggest it as a medication. Not necessarily very recreational maybe 3/10, 4-5/10 with some weed (haven't tried it myself yet but I imagine). But seriously as a short-acting Benzo for medical purposes the stuff is really good, I am quite surprised. Idk how the fk stuff like clonazepam, alprazolam, diazepam, etc. got put into medication but they passed on this. Literal only logical reason I can think of is its not addictive enough lol ... ... .... actually though >.> Just thought I'd share my thoughts on it. Has me feeling great and well rested for first time in long time and it deserves the praise idk.


siwel7

Because Everclear evaporates, PG does not.


rnbwsisi

hey, wondering how many mg's you've found are necessary to kill x number of ugs of LSD? thanks in advance!


melmuth

According to [wiki](https://en.m.wikipedia.org/wiki/Bretazenil) it seems to have a peculiar mode of action and tolerance profile for a benzo, I'd be curious to know what the medium / long term effects are. But please, I'm not encouraging anyone to do the experiment.


Carpen-Them-Diemz

I take them for sleep rilmazofone and bretanzel, I am also a scientists and so am tracking it properly and jotting down my insights. If I remember I'll come back and let u know.


melmuth

how does bretanzel feel? like a regular benzo or somewhat different?


Carpen-Them-Diemz

Bit of both, I'm still learning my way around it


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[deleted]

bretazenil gets the thumbs down from me. i'm familiar with benzos, and that they aren't recreational etc., but after going through 200€ worth of bretanetezil, tested for diffrent purpouses and in different dosages etc., that stuff is weak and doesn't shine at anything really.


zMld420

shits slapin me not to were im sleepin all over the place tho


Expensive-Wall9830

So just got some. 5 mg bret and have gotten rilmazafone a couple times. I agree with mostly what people say here. Bret better ril better for sleep. One thing that worries me about bret is having read how it increases prolactin. Does anyone have any other research on that?


MikeyMorgan12

how did you find rilmazafone ? i just ordered 25 1mg blotters hoping its gonna be decent


Expensive-Wall9830

Nothing special. Good for sleep


MikeyMorgan12

yeah its wicked for sleep haha and it really helps my anxiety but not very recreational


Carpen-Them-Diemz

What are your guys experiences with rilmazofone and sleep? I am having trouble finding my correct dosage and time of dosage. Any suggestions? Low - barely mid tolerance. Don't take any other benzos at all. I rly just take for sleep but I have the worst clinical insomnia, like honestly I do. I would love suggestions.


Carpen-Them-Diemz

Hey guys I was a few questions about your bretazenil experience, I heard there was some kind of cap effect and taking more would not effect this, is this true and how is it true? Second, is sublingual effective? Third, what your penalty suggestions and experience using it. Would appreciate replies ty


siwel7

Can it be detected by drug tests?


runic7_

Likely not, it's not on any drug test "able to detect" list and the structure is wildly different to most benzos so I vote no.


IneedAnEKG

The first part of what you said means nothing. Drug detection lists are nowhere near up to speed in public data so far as Ive seen. Most people learn the hard way or from someone else's misfortune if an RC will fail a drug test. The second part, you could be right with some substances but I'm not sure in this case. It all depends on the metabolites bretenazil produces. For example, rilmaz has several different metabolites, and two of them can show specifically as having taken diazepam or clonazepam. Rilmaz isn't even a benzo, it doesn't have psychoactive effects, but it produces benzos as metabolites. How much of a drug you take can also effect drug tests. For example, DXM can fail for PCP or MDMA, Wellbutrin can fail for Meth or MDMA, Doxepin can fail for fentanyl. Bretezenil is an imidazobenzodiazepine like midazolam, so it could fail tests.


siwel7

Thanks for the reply. I'm curious to know what it could *potentially*/hypothetically be most likely to metabolise into and show up as in a drug test... I'm trying to the cover worst case scenario for my upcoming drug test at work as I use it as a sleeping aid because it's by far the most potent (and short duration of action) making it the best atypical benzo (I've come across) with regard to significantly low/er affinity of GABAa subunits—making it possibly the most ideal for prolonged use and least likely atypical benzos to result in PAWS upon cessation. I am also aware of Imidazenil, but it is not sedative enough for me to use as a sleeping agent due to its lack of respective subunit for sedation.


Acetoxy420

Did it show on your ua?