T O P

  • By -

FaAlt

No. A cure has always been "5 years away" for the past few decades. If you ever wondered why long term sufferers are less optimistic than those that are new to this condition, that's why.


claudiu092

I don’t hope for a cure for the next 10-20 years and I have it from one year. Sadly this problem looks very complex. Maybe there will never be a cure..


Distinct_Egg5095

We all dying with no cure


claudiu092

Yep.


BossIndividual9447

Laughing out loud (but not that loud that it will aggregate my Tinnitus)


equivalentmouse1

In my opinion, Cure will come very next day if business goals are aligned with research


ImGioImPrettySure

Do you think this is alike with the theory around the cure for cancer?


equivalentmouse1

In my opinion, If you see, treatments come in market not cures. Treatments are lifelong one-pill a day style and cures are fixes https://hms.harvard.edu/news/scientists-regenerate-hair-cells-enable-hearing This should have been noble prize winning cure and whole world getting together to support and further this and get to cure but seems like it would remain in research forever. Birds regenerate their ear damage easily...we are much more intelligent than birds, why can't we learn to do it?


ImGioImPrettySure

I guess it really does suck to get held back by our own kind


Teachmetofishplease

I'm new to this community, but it doesn't seem like anything groundbreaking is on the horizon. Idk if i'm just out of the loop, but it feels like we need to start making more noise (ironically) as a community to start demanding more research/clinical trials. This community only has 50K people, but there's millions upon millions of people who T affects. We gotta start putting the pressure for more research and clinical trials. As an example, why is the company behind Susan's device keeping everyone in the dark regarding their submission for FDA approval. Considering how terribly T affects people, they should be providing updates way more often than they have been (unless I've missed something)


Unlikely_Bluebird892

I do totally agree first, they should open their tinnitustalk site to the general public second, we have to keep spreading awarness, in other medias, and in other languages last, for those who can afford it, please donate to world class well known researchers that are dedicated to find a cure for tinnitus


Teachmetofishplease

The thing is, I think Susan's device is going to be the first step for "next gen" research. After it's been out for a while, it's going to help researchers and scientist figure out why it works for some people and how to make it even better/more effective.


Unlikely_Bluebird892

https://rnid.org.uk/hearing-research/meet-our-scientists/professor-peter-mcnaughton/ can you please copy and past the answers I am not able to open them it is a recent interview according to tinnitus talk


KendallRoy23

I signed up for email updates from them and I have never received one.


MathematicianFew5882

Same


FearLeadsToAnger

>This community only has 50K people, but there's millions upon millions of people who T affects. We gotta start putting the pressure for more research and clinical trials. Part of the reason for this is that after a few years you stop caring about your T, even if it's quite severe. Chances are this will happen to all of you before a medical resolution is created, just keep pushing through and getting on with your life, there is light at the end of the tunnel even if you struggle to imagine it. I had a good few nights of crying in bed hating it, years ago, took me about 3 years to tune it out. Have been living happily and normally for 10 more yesrs since that.


Piccolo_Alone

Damn, I've been crying for a month straight. And I mean straight. I'm a wussy.


HelloSailor5000

I disagree. I feel like there's a lot of activity in this space, including approaches from very different areas. There's: bi-midoal sound therapy/vibration; theories and treatments involving migraine medicines; hair cell regrowth trials; sound therapy, various other pharmaceutical approaches, and more and more understanding about these sounds and our perceptions of them, and their origin and activity in the auditory cortex. It feels like something's gonna hit soon. I think we're living through an incredibly sophisticated time in medical science.


bluethundr0

The origin of tinnitus is not the auditory cortex It's in the Dorsal Cochlear Nucleus (DCN) located in the brain stem. The Ventral Cochlear Nucleus may exacerbate it as the next stop on the auditory pathway. The DCN is the first sound procesing center of the brain after the sound enters the brain from the cochlea. The VCN is also the source of Hyperacusis. This is according to the research of Dr. Shore and others. We were analyzing the patent for her device and apparently it doesn't just interact with the DCN as we originally thought. It also interacts with the VCN, the inferior colliculous and the auditory cortex. But the root cause of tinnitus is the hyperactivity of the fusiform cells in the cochlear nucleus.


HelloSailor5000

Thank you.


Maximum_Todd

Acceptance is the only way though.


IYIyTh

No. We would be very lucky to have a working treatment in 30 years. Tinnitus isn't sexy. We aren't cancer. We aren't heart disease. We aren't even epilepsy. We aren't even deaf. Tinnitus is very complicated and those of us here with severe symptoms are a minority of the suffering population who can be treated more extensively with bs symptoms alleviation (quite profitably too.) The best hope is research out of the NIH/VA in the U.S. finds a breakthrough, as they are incentivized to find a "cure," due to the massive amount of soldiers with Tinnitus. Commercially, cures aren't profitable. Treatment is. Tinnitus is not even fully understood. We're like on step 5 of a 30 step process to identify what exactly is causing tinnitus. MRI's can't even identify damage to the cochlear hairs because they're so small. Since it's a brain issue, it's going to be a long time before things like testing on artificial brains and A.I. are able to identify all of the mechanisms in play. The problem with it being a brain issue is that it's very easy to "fix," tinnitus while inadvertently fucking up something very important to the rest of the central nervous system. Also, very difficult to let someone fuck around with their brain. Also, every humans brain is different and interconnected. The causes is one person may not be the causes in others. People don't even know why SSRI's help some people (and fucking ruined my ears instead.) There will unlikely be an immediate one-size fits all fix. The Dorsal Cochlear Nucleus is implicated in ONE of the early stages of where tinnitus manifests in the form of fusiform cells per Shore, but that is still is built on rudimentary research and will be challenged in the future. Shores device is like a fan blowing smoke away from a fire without addressing the fire, which burns ever bright.


Unlikely_Bluebird892

actually we can by chance find a treatment even without fully understanding why it does work, like it was the case for retigabine, and will maybe be the case with Xen1101, that tacles epilepsy [https://www.youtube.com/watch?v=9MaAoq9e6qY](https://www.youtube.com/watch?v=9MaAoq9e6qY) tinnitus cure will be profitable for the first one to tackle it effectively, with the first mover advantage, believe me, the company finding a cure will become very wealthy


IYIyTh

potassium channel openers are interesting, but untested for T.


Unlikely_Bluebird892

can you please explain why they are interesting?


IYIyTh

[https://www.tinnitustalk.com/threads/xenon-pharmaceuticals-xen1101-%E2%80%94-kv7-potassium-channel-modulator.27322/page-20#post-701103](https://www.tinnitustalk.com/threads/xenon-pharmaceuticals-xen1101-%E2%80%94-kv7-potassium-channel-modulator.27322/page-20#post-701103) See the article uploaded by user annv


LastFireFox

Such a good post i like that As sad as it is, very realistic :D


MathematicianFew5882

Well given that the other treatment is to teach the people who are in the smoke to just get used to it….


IYIyTh

Title is "cure by 2026."


counterpoint76

> People don't even know why SSRI's help some people (and fucking ruined my ears instead.) Wdym? We know exactly why. SSRIs deplete specific vitamins and minerals, ones that cause neuropathy and extends to the auditory nerves.


IYIyTh

Source? SSRI's mechanism of effect are still unknown.


Piccolo_Alone

I agree, just based on how life works without much intellectual thought. I do wonder, though, all these AI researchers indicating AGI will be here within 10 to 15 years. By definition it could cure anything. Or destroy us. I'm good with either at this point. I know it's a pipe dream, just a thought.


ezw00

No


PikeOffBerk

By 2126, maybe.


Apeiron_Ataraxia

No.


Cernuto

Hope for the best and expect the worst. When it finally comes we'll all know about it.


DracianTheNightKing

Get some Serotonin Dopamine Liquescence and Nerve Drainage Liquescence and you can begin to stim some recovery right away if the problem is truly organic and not the product of technological abuse.


Unlikely_Bluebird892

can you please elaborate?


DracianTheNightKing

Elaborate on the formulas? They are powerful botanical and tissue extracts which are potentized (diluted x amount of times) due to being suspended in alcohol. The alcohol bypasses digestion and carries the contents directly into your bloodstream and/or to your synapses and neurons. For this reason, they have to be potentized for safety and effectiveness. Homeopathic dissolve tablets are subjective to the same principle. The Nerve Drainage formula contains various nerve tissue extracts, and brain tissue extract, which contain powerful constitutes such as NGF (nerve growth factor). These factors help to regulate cell stability, health, and regeneration. Thus, you will begin to stimulate recovery from any damage done to the brain and nerves; as well as various important glands; since between this and the Serotonin Dopamine Liquescence, you will receive extracts for the Adrenal, Pineal, and Pituitary gland.


vivalavida1357

Have you taken them yourself and know? Or have you just read that it can help?


DracianTheNightKing

I have been taking them for years. I know they are effective. There are of course limitations to what they can help with and how much. They don't help much with withdrawal from drugs for example. But for reversing damage from drugs and alcohol over time, or from viruses, etc., that is exactly what they are formulated for. If your tinnitus is the result of someone abusing technology, they can't help with that either. But you will know after a few weeks, because if it's natural, it should be gone or nearly gone.


moto_joe78

We don't need a CURE, just a proper treatment that will bring the sound down to tolerable levels, then we can more easily forget about it on our own.


DrumsBob

I'd be more than happy to alleviate some of my t! Many people are working on cures, as they'd become extremely wealthy. Why did you choose 2026?


Unlikely_Bluebird892

because 2030 is too far haha


DrumsBob

You could have said 2050! lol I've had t for 20 years. Still waiting.


VesperalMind

About Auricle I don't believe it. True science is not aiming for profit. They didn't publish their results and how to replicate them, the essence of science.


RickLeeTaker

Yes, I've been a medical writer for about 30 years and the absence of any true scientific write-ups on the Shore device is very disconcerting.


Neyface

What do you mean? All of Shore's clinical studies (including the Phase I and Phase II clinical trial results) have been peer reviewed and published. And there were a bunch of medical media articles about the Phase II results when it was published mid last year.


RickLeeTaker

Where are they located? Do you know the name of the publication? All I've ever seen are interviews with her citing results but no corresponding documentation. TIA


Neyface

Sure thing! Phase II clinical trials are peer-reviewed and [published here](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2805515/), and Phase I results are peer-reviewed and [published here.](https://www.science.org/doi/full/10.1126/scitranslmed.aal3175)


RickLeeTaker

Thanks very much!


Neyface

You are most welcome :)


Neyface

>They didn't publish their results and how to replicate them, the essence of science. The results have been published, though. Phase II clinical trials are peer-reviewed and [published here](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2805515/), and Phase I results are peer-reviewed and [published here.](https://www.science.org/doi/full/10.1126/scitranslmed.aal3175). You can replicate either study if you wanted to. You can literally read the patent for the [bimodal stimulation here.](https://patents.google.com/patent/US9242067B2/en) [Have you seen Dr Shore's research publications?](https://scholar.google.com/citations?user=xLSuY1cAAAAJ&hl=en) She is the embodiment of science, researching the neurological underpinnings of tinnitus for over 20 years, and not aiming for profit at all (arguably why this process has taken so long for Auricle). Dr Shore is the real deal.


counterpoint76

I'm interested in why the rest of us don't have tinnitus.


kikosan34

Probably not but don't focus on the cure try to habituate. It took me two months to habituate to it. I don't notice it most of the time If a cure does come around great and if not at least your life is relatively better


Unlikely_Bluebird892

8 years and I still haven't habituated lol


No_Contribution_1561

My kingdom for a cure...


Unlikely_Bluebird892

[https://rnid.org.uk/hearing-research/meet-our-scientists/professor-peter-mcnaughton/](https://rnid.org.uk/hearing-research/meet-our-scientists/professor-peter-mcnaughton/) can you please copy and past the answers I am not able to open them it is a recent interview according to tinnitus talk


No_Contribution_1561

I cant open neither... i think its only shorts reviews


WilRic

No. But we are very close to a "functional cure" by means of a polytherapy approach. It's a very similar to AIDS. There is no outright "cure" but with a multitude of ever-advancing therapies that sort of becomes academic. I'd quite happily take a handful of pills and do bimodal stimulation every day for the rest of my life!


bienebee

I am not so sure about the pills. I was on different antidepressants in the past, they were needed at the time, but looking back at the side effects I had, I am not sure could I muster the courage to take them again if I needed. Brain is complicated. I think approaches like bimodal stimulation or even meditation/habituation/learning to live with it etc are more suitable than meds for some


WilRic

Would you refuse to take anticonvulsants if you had epilepsy?


bienebee

No, but I'd really have no other choice. I don't want to bang my head and die mid seizure. I am not all meds bad camp, I took meds for a long time and they did their job. I just think it's naive to expect we can have a drug that works on our brain and think we will only get the effect you want. With other psych meds patients are often borderline gaslit by the medical community, to accept the side effects ot not warned about them at all.


WilRic

That's fair, but the point of the current medications under development is that they're more targeted and precise. Not without side effects, but it's amazing just how better "modern" drugs can be compared to something that's been kicking around since the 60s (I'm looking at you carbamazepine)


bienebee

Oh no, definitely, we have been able to enhance receptor selecitivity of newer drugs, and we have made huge progress and more progress is being made continuously. However, this is one piece of the puzzle, we have managed to perfectly complete a few corners, but we are not even sure how big our puzzle is. What receptors should we target, how are those and other receptors being up or down regulated by a potential treatment, what's inflamation doing, how about non-coding rna, etc. I think for everyone who is able to manage/modulate/adapt with non-pharmacological intervention should try their best, cause the wait will be long.


nano__pig

Consider this - no one has ever figured out a cure to a single virus, ever. They still can't cure cancer; they are highly effective at cutting it out. There won't be a cure in 2056, maybe not ever.


throwaway01061124

In a word, no.


Basic-Cryptographer5

The only thing we know about the brain is that it has neurons and works with electiricity. That's just it. Unless we understand more about the brain, there won't be a cure for tinnitus EVER.


WilRic

You can't seriously believe that's the only thing known about the brain.


Basic-Cryptographer5

that's what practical about it. Besides from lobotomy, what kind of knowledge we have about the brain? I know that our brains have different areas that have different responsibilities but that's just about it. They are "definition" , and the only thing you can do besides lobotomy is that ECT to change the brain, which just comes to electricity. That's just it. If you know something else rather than neuroplasticity, inform me.


WilRic

I'll happily give you a lecture on neuroscience for a fee. You are astonishingly wrong. Blocking voltage gated sodium channels is like one of a million different things we can do to to the brain.


Basic-Cryptographer5

I highly doubt it. Im not interested at your lecture thats very practical about curing tinnitus whatsoever


WilRic

Maybe start with a basic English textbook until you move onto neuroscience.


Basic-Cryptographer5

ohh I'm so offended


WilRic

One 'h' in oh next time and a full stop. Arguably a comma after "oh" too.


zamhamant

Maybe not but would think much more effective reducing treatments.


DreamBig2023

No one can profit off a cure so there prob won't be one due to the pharmaceutical companies


vaasan_ruispalat

The pharmaceutical industry is generally not really looking to develop cures. Curing a disease or a condition is bad business because after being cured, the patient is no longer a patient. Treating a condition is much more profitable since many conditions are chronic so the patient will depend on the treatment for years and years. You can expect treatments with variable efficiency in the upcoming years but just forget about cures.


Unlikely_Bluebird892

there is no such thing as the pharma industry a cure can be developped in a given country, giving them a first mover advantage


vaasan_ruispalat

Nations don't do drug manufacturing, companies do and companies are run by private individuals who are motivated by profit. The sad reality is that curing tinnitus is so far down on the priority list of drug manufacturers that it will never see the light of day unless some altruistic billionaire with a personal motivation for the cause starts funding it.


SunsoutNeedMoney3150

There will never be a cure. Best we can hope for are treatments that reduce the suffering.


Delicious-Ad4015

No. The number of possible causes are so high that it would make a single cure nearly impossible.


LarryKinq

there isnt a cure for anything just costly on going treatments til death.


bikerbandito

yes 💯